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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T04:39:42Z","timestamp":1688445582834},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Miniature Schnauzers are predisposed to develop pancreatitis, with familial hypertriglyceridemia (HTG) described as a potential risk factor. Diagnosing pancreatitis in dogs is based on the integration of serum canine-specific pancreatic lipase (cPLI) concentration, clinical presentation, and diagnostic imaging findings. However, markers of systemic inflammation and antiprotease activity have not been extensively investigated in the characterization and prognostication of pancreatitis in dogs. Serum concentrations of alpha1-proteinase inhibitor (\u03b11PI; as a marker of systemic antiprotease response) and calprotectin and S100A12 (as markers of systemic inflammation) were measured in serum samples from 35 Miniature Schnauzers diagnosed with pancreatitis (serum cPLI concentration >400 \u03bcg\/L, clinical signs, abdominal imaging findings). These markers were evaluated for possible associations with patient characteristics, clinical presentation, risk factors for pancreatitis, and outcome. The study showed that biomarkers of systemic inflammation and antiprotease activity are commonly increased in Miniature Schnauzers with pancreatitis. Whereas serum calprotectin and S100A12 concentrations were found to have limited utility in differentiating pancreatitis presentations, serum \u03b11PI concentrations and potentially also the serum calprotectin-to-S100A12 ratio might be non-invasive surrogate markers of disease severity in dogs with pancreatitis.<\/jats:p>","DOI":"10.3390\/vetsci10070428","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T04:49:27Z","timestamp":1688359767000},"page":"428","source":"Crossref","is-referenced-by-count":0,"title":["Serum \u03b11-Proteinase Inhibitor, Calprotectin, and S100A12 Concentrations in the Characterization of Pancreatitis in Dogs"],"prefix":"10.3390","volume":"10","author":[{"given":"Annina N.","family":"Jandel","sequence":"first","affiliation":[{"name":"Department for Small Animals, College of Veterinary Medicine, University of Leipzig, DE-04103 Leipzig, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-3485-5157","authenticated-orcid":false,"given":"Romy M.","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Department for Small Animals, College of Veterinary Medicine, University of Leipzig, DE-04103 Leipzig, Germany"},{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA"}]},{"given":"Henri","family":"Sander","sequence":"additional","affiliation":[{"name":"Department for Small Animals, College of Veterinary Medicine, University of Leipzig, DE-04103 Leipzig, Germany"}]},{"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA"}]},{"given":"Niels","family":"Gr\u00fctzner","sequence":"additional","affiliation":[{"name":"Ruminant and Swine Clinic, Free University of Berlin, DE-14165 Berlin, Germany"},{"name":"VetaRegio GmbH, DE-06366 K\u00f6then, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9508-0271","authenticated-orcid":false,"given":"Panagiotis G.","family":"Xenoulis","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA"},{"name":"Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1939-1676.2012.00949.x","article-title":"Pathophysiology of acute pancreatitis: Potential application from experimental models and human medicine to dogs","volume":"26","author":"Mansfield","year":"2012","journal-title":"J. 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