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Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41598-018-19690-7","article-title":"A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection","volume":"8","author":"Horsley","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02512-5","article-title":"Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: An in vitro study","volume":"12","author":"Yuan","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhang, M., Xu, M.X., Zhou, Z., Zhang, K., Zhou, J., Zhao, Y., Wang, Z., and Lu, M.J. (2014). The differentiation of human adipose-derived stem cells towards a urothelium-like phenotype in vitro and the dynamic temporal changes of related cytokines by both paracrine and autocrine signal regulation. 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Signal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/jphp.13145","article-title":"Assessing the cytotoxic potential of glycoalkaloidic extract in nanoparticles against bladder cancer cells","volume":"71","author":"Miranda","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fphys.2017.00605","article-title":"Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening","volume":"8","author":"Amaral","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/pros.23404","article-title":"Estradiol promotes epithelial-to-mesenchymal transition in human benign prostatic epithelial cells","volume":"77","author":"Shi","year":"2017","journal-title":"Prostate"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1095\/biolreprod.116.143446","article-title":"Three-dimensional testicular organoid: A novel tool for the study of human spermatogenesis and gonadotoxicity in vitro","volume":"96","author":"Pendergraft","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Eder, T., Weber, A., Neuwirt, H., Gr\u00fcnbacher, G., Ploner, C., Klocker, H., Sampson, N., and Eder, I.E. (2016). Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid Culture. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091458"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3739251","DOI":"10.1155\/2018\/3739251","article-title":"The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures","volume":"2018","author":"Nguyen","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1167\/iovs.18-25054","article-title":"The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy","volume":"59","author":"Brinks","year":"2018","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Jun, D.Y., Kim, S.Y., Na, J.C., Lee, H.H., Kim, J., Yoon, Y.E., Hong, S.J., and Han, W.K. (2018). Tubular organotypic culture model of human kidney. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206447"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2017.02.018","article-title":"Efficacy of photochemical internalisation using disulfonated chlorin and porphyrin photosensitisers: An in vitro study in 2D and 3D prostate cancer models","volume":"393","author":"Woodhams","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.isci.2019.01.028","article-title":"Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate Organoids","volume":"12","author":"Richards","year":"2019","journal-title":"iScience"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Georgakopoulos, N., Prior, N., Angres, B., Mastrogiovanni, G., Cagan, A., Harrison, D., Hindley, C.J., Arnes-Benito, R., Liau, S.-S., and Curd, A. (2020). Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids. BMC Dev. Biol., 20.","DOI":"10.1186\/s12861-020-0209-5"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1800249","DOI":"10.1002\/mabi.201800249","article-title":"Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture","volume":"19","author":"Georgakopoulos","year":"2019","journal-title":"Macromol. Biosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1073\/pnas.90.8.3334","article-title":"Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane","volume":"90","author":"Zhang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/09205063.2018.1505264","article-title":"Bioactive 3D scaffolds self-assembled from phosphorylated mimicking peptide amphiphiles to enhance osteogenesis","volume":"30","author":"Liang","year":"2019","journal-title":"J. Biomater. Sci. Polym. Ed"},{"key":"ref_23","unstructured":"Rasband, W.S. (2023, March 01). ImageJ. U.S. National Institutes of Health, Available online: http:\/\/rsb.info.nih.gov\/ij\/."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Amaral, R., Zimmermann, M., Ma, A.H., Zhang, H., Swiech, K., and Pan, C.X. (2020). A Simple Three-Dimensional In Vitro Culture Mimicking the In Vivo-Like Cell Behavior of Bladder Patient-Derived Xenograft Models. Cancers, 12.","DOI":"10.3390\/cancers12051304"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/jcmm.16132","article-title":"Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models","volume":"25","author":"Caston","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1089\/ten.tea.2019.0045","article-title":"Hypoxia-Preconditioned Adipose-Derived Endothelial Progenitor Cells Promote Bladder Augmentation","volume":"26","author":"Zhao","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.actbio.2019.11.026","article-title":"Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model","volume":"102","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"055005","DOI":"10.1088\/1748-6041\/10\/5\/055005","article-title":"Urethral reconstruction with a 3D porous bacterial cellulose scaffold seeded with lingual keratinocytes in a rabbit model","volume":"10","author":"Huang","year":"2015","journal-title":"Biomed. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2041731421998840","DOI":"10.1177\/2041731421998840","article-title":"Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study","volume":"12","author":"Morgante","year":"2021","journal-title":"J. Tissue Eng."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wehrle, E., Rubert, M., and M\u00fcller, R. (2021). 3D Bioprinting of Human Tissues: Biofabrication, Bioinks, and Bioreactors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083971"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kim, M.J., Chi, B.H., Yoo, J.J., Ju, Y.M., Whang, Y.M., and Chang, I.H. (2019). Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0223689"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Berg, J., Weber, Z., Fechler-Bitteti, M., Hocke, A.C., Hippenstiel, S., Elomaa, L., Weinhart, M., and Kurreck, J. (2021). Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors. Viruses, 13.","DOI":"10.3390\/v13081590"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2102624","DOI":"10.1002\/adma.202102624","article-title":"Production of Multiple Cell-Laden Microtissue Spheroids with a Biomimetic Hepatic-Lobule-Like Structure","volume":"33","author":"Hong","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.actbio.2016.12.008","article-title":"3D bioprinting of urethra with PCL\/PLCL blend and dual autologous cells in fibrin hydrogel: An in vitro evaluation of biomimetic mechanical property and cell growth environment","volume":"50","author":"Zhang","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"664404","DOI":"10.3389\/fsurg.2021.664404","article-title":"Current Applications and Future Directions of Bioengineering Approaches for Bladder Augmentation and Reconstruction","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Lee, S., Kang, S.J., Choi, Y.W., Choi, S.Y., Park, J.Y., and Chang, I.H. (2021). Establishment of Three-Dimensional Bioprinted Bladder Cancer-on-a-Chip with a Microfluidic System Using Bacillus Calmette-Gu\u00e9rin. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168887"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Wang, H., Ding, Q., Xing, Y., Xu, Z., Lu, C., Luo, D., Xu, L., Xia, W., and Zhou, C. (2018). Establishment of patient-derived tumor spheroids for non-small cell lung cancer. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194016"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.drudis.2016.07.003","article-title":"Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling","volume":"21","author":"Skardal","year":"2016","journal-title":"Drug Discov. Today"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.bbagen.2014.01.010","article-title":"Extracellular matrix: A dynamic microenvironment for stem cell niche","volume":"1840","author":"Gattazzo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrm3873","article-title":"Three-dimensional organotypic culture: Experimental models of mammalian biology and disease","volume":"15","author":"Shamir","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.addr.2014.10.015","article-title":"Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development","volume":"79\u201380","author":"Unger","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/embor.2011.249","article-title":"Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance","volume":"13","author":"Yagi","year":"2012","journal-title":"EMBO Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1128\/IAI.74.1.750-757.2006","article-title":"Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells","volume":"74","author":"Smith","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/pros.20628","article-title":"Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: Role of extracellular calcium","volume":"67","author":"Tyson","year":"2007","journal-title":"Prostate"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrurol.2017.19","article-title":"Patient-derived xenografts as in vivo models for research in urological malignancies","volume":"14","author":"Inoue","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrurol.2017.65","article-title":"The potential of organoids in urological cancer research","volume":"14","author":"Wang","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Okada, S., Vaeteewoottacharn, K., and Kariya, R. (2019). Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models. Cells, 8.","DOI":"10.20944\/preprints201906.0002.v1"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"76374","DOI":"10.18632\/oncotarget.13062","article-title":"Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts","volume":"7","author":"Wei","year":"2016","journal-title":"Oncotarget"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.trsl.2015.02.001","article-title":"Patient-derived bladder cancer xenografts: A systematic review","volume":"166","author":"Bernardo","year":"2015","journal-title":"Transl. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e5981","DOI":"10.7717\/peerj.5981","article-title":"A systematic review of the validity of patient derived xenograft (PDX) models: The implications for translational research and personalised medicine","volume":"6","author":"Collins","year":"2018","journal-title":"PeerJ"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/2159-8290.CD-14-0001","article-title":"Patient-derived xenograft models: An emerging platform for translational cancer research","volume":"4","author":"Hidalgo","year":"2014","journal-title":"Cancer Discov."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fcell.2020.00166","article-title":"Modeling Cell Communication in Cancer with Organoids: Making the Complex Simple","volume":"8","author":"Fiorini","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1002\/ctm2.95","article-title":"Conditional reprogramming: Modeling urological cancer and translation to clinics","volume":"10","author":"Liu","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12943-021-01426-3","article-title":"Patient derived organoids in prostate cancer: Improving therapeutic efficacy in precision medicine","volume":"20","author":"Pamarthy","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/22780","article-title":"Creation of human tumour cells with defined genetic elements","volume":"400","author":"Hahn","year":"1999","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/term.1923","article-title":"Qualifying stem cell sources: How to overcome potential pitfalls in regenerative medicine","volume":"10","author":"Reinke","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrm.2016.8","article-title":"A decade of transcription factor-mediated reprogramming to pluripotency","volume":"17","author":"Takahashi","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nm.4238","article-title":"Patient-derived induced pluripotent stem cells in cancer research and precision oncology","volume":"22","author":"Papapetrou","year":"2016","journal-title":"Nat. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hwang, J.W., Desterke, C., F\u00e9raud, O., Richard, S., Ferlicot, S., Verkarre, V., Patard, J.J., Loisel-Duwattez, J., Foudi, A., and Griscelli, F. (2019). iPSC-Derived Embryoid Bodies as Models of c-Met-Mutated Hereditary Papillary Renal Cell Carcinoma. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194867"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41576-019-0100-z","article-title":"Induced pluripotent stem cells in disease modelling and drug discovery","volume":"20","author":"Rowe","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Palechor-Ceron, N., Krawczyk, E., Dakic, A., Simic, V., Yuan, H., Blancato, J., Wang, W., Hubbard, F., Zheng, Y.L., and Dan, H. (2019). Conditional Reprogramming for Patient-Derived Cancer Models and Next-Generation Living Biobanks. Cells, 8.","DOI":"10.3390\/cells8111327"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-017-0745-1","article-title":"Generation of stable PDX derived cell lines using conditional reprogramming","volume":"16","author":"Borodovsky","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2019.06.165","article-title":"Fidelity of a PDX-CR model for bladder cancer","volume":"517","author":"Mondal","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.eururo.2019.06.016","article-title":"Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells","volume":"76","author":"Kettunen","year":"2019","journal-title":"Eur. Urol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1158\/1078-0432.CCR-20-1569","article-title":"Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling","volume":"26","author":"Muniyan","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s42003-022-03133-1","article-title":"OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR","volume":"5","author":"Fu","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_67","first-page":"3042","article-title":"CWR22: The first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar","volume":"56","author":"Nagabhushan","year":"1996","journal-title":"Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110109","DOI":"10.1016\/j.celrep.2021.110109","article-title":"Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer","volume":"37","author":"Long","year":"2021","journal-title":"Cell Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1158\/0008-5472.CAN-13-2921-T","article-title":"High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development","volume":"74","author":"Lin","year":"2014","journal-title":"Cancer Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ci, X., Hao, J., Dong, X., Xue, H., Wu, R., Choi, S.Y., Haegert, A.M., Collins, C.C., Liu, X., and Lin, D. (2020). Conditionally Reprogrammed Cells from Patient-Derived Xenograft to Model Neuroendocrine Prostate Cancer Development. Cells, 9.","DOI":"10.3390\/cells9061398"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41467-021-27322-4","article-title":"Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states","volume":"13","author":"Song","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1158\/1078-0432.CCR-18-0409","article-title":"A PDX\/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening","volume":"24","author":"Beshiri","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7704","DOI":"10.1038\/s41598-017-07979-y","article-title":"The miR-183 family cluster alters zinc homeostasis in benign prostate cells, organoids and prostate cancer xenografts","volume":"7","author":"Dambal","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.1038\/s41467-021-26901-9","article-title":"The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer","volume":"12","author":"Singh","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1038\/onc.2012.477","article-title":"Chromatin H3K27me3\/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells","volume":"32","author":"Curry","year":"2013","journal-title":"Oncogene"},{"key":"ref_76","first-page":"1107","article-title":"High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids","volume":"26","author":"Choo","year":"2021","journal-title":"Adv. Sci. Drug Discov."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1038\/s41598-021-83662-7","article-title":"A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture","volume":"11","author":"Cai","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1073\/pnas.1803595116","article-title":"Mouse and human urothelial cancer organoids: A tool for bladder cancer research","volume":"116","author":"Mullenders","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cell.2018.03.017","article-title":"Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer","volume":"173","author":"Lee","year":"2018","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e1248","DOI":"10.1002\/cti2.1248","article-title":"Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro","volume":"10","author":"Yu","year":"2021","journal-title":"Clin. Transl. Immunology"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wei, Y., Amend, B., Todenh\u00f6fer, T., Lipke, N., Aicher, W.K., Fend, F., Stenzl, A., and Harland, N. (2022). Urinary Tract Tumor Organoids Reveal Eminent Differences in Drug Sensitivities When Compared to 2-Dimensional Culture Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116305"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41586-020-3034-x","article-title":"Creation of bladder assembloids mimicking tissue regeneration and cancer","volume":"588","author":"Kim","year":"2020","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"610","DOI":"10.5966\/sctm.2013-0131","article-title":"Induction of human embryonic and induced pluripotent stem cells into urothelium","volume":"3","author":"Osborn","year":"2014","journal-title":"Stem. Cells Transl. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.3390\/ijms15057139","article-title":"Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system","volume":"15","author":"Kang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s13238-019-0649-5","article-title":"Continuous culture of urine-derived bladder cancer cells for precision medicine","volume":"10","author":"Jiang","year":"2019","journal-title":"Protein. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0248-4900(94)80013-8","article-title":"A new method for the 3-D in vitro growth of human RT112 bladder carcinoma cells using the alginate culture technique","volume":"82","author":"Boxberger","year":"1994","journal-title":"Biol. Cell"},{"key":"ref_87","first-page":"1678","article-title":"Identification of genes involved in human urothelial cell-matrix interactions: Implications for the progression pathways of malignant urothelium","volume":"61","author":"Smith","year":"2001","journal-title":"Cancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.biomaterials.2017.08.041","article-title":"Tissue-engineered human 3D model of bladder cancer for invasion study and drug discovery","volume":"145","author":"Goulet","year":"2017","journal-title":"Biomaterials"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Tracey, A.T., Murray, K.S., Coleman, J.A., and Kim, K. (2020). Patient-Derived Xenograft Models in Urological Malignancies: Urothelial Cell Carcinoma and Renal Cell Carcinoma. Cancers, 12.","DOI":"10.3390\/cancers12020439"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"137ra75","DOI":"10.1126\/scitranslmed.3003643","article-title":"A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma","volume":"4","author":"Sivanand","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1096\/fj.201700740R","article-title":"Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy","volume":"32","author":"Wang","year":"2018","journal-title":"FASEB J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4939-8600-2_6","article-title":"Three-Dimensional Cell Culture Model Utilization in Renal Carcinoma Cancer Stem Cell Research","volume":"1817","author":"Brodaczewska","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3389\/fonc.2019.01302","article-title":"Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics","volume":"9","author":"Zanjani","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"17076","DOI":"10.1038\/s41598-021-96288-6","article-title":"Single cell organization and cell cycle characterization of DNA stained multicellular tumor spheroids","volume":"11","author":"Olofsson","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Batchelder, C.A., Martinez, M.L., and Tarantal, A.F. (2015). Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143849"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41419-019-1453-0","article-title":"Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases","volume":"10","author":"Grassi","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4111\/icu.2020.61.2.216","article-title":"Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma","volume":"61","author":"Na","year":"2020","journal-title":"Investig. Clin. Urol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.euf.2019.06.009","article-title":"Tracing Clonal Dynamics Reveals that Two- and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma","volume":"7","author":"Bolck","year":"2021","journal-title":"Eur. Urol. Focus"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Nyga, A., Stamati, K., Redondo, P.A., Azimi, T., Feber, A., Neves, J.B., Hamoudi, R., Presneau, N., El Sheikh, S., and Tran, M.G.B. (2022). Renal tumouroids: Challenges of manufacturing 3D cultures from patient derived primary cells. J. Cell Commun. Signal.","DOI":"10.1007\/s12079-022-00666-2"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3389\/fonc.2020.01775","article-title":"Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy","volume":"10","author":"Esser","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41563-021-01057-5","article-title":"Next-generation cancer organoids","volume":"21","author":"LeSavage","year":"2022","journal-title":"Nat. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1089\/bio.2019.0062","article-title":"Cryopreservation of Viable Human Tissues: Renewable Resource for Viable Tissue, Cell Lines, and Organoid Development","volume":"18","author":"He","year":"2020","journal-title":"Biopreserv. Biobank."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41467-020-15155-6","article-title":"An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity","volume":"11","author":"Calandrini","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41467-020-14700-7","article-title":"Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients","volume":"11","author":"Fendler","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e883","DOI":"10.1002\/ctm2.883","article-title":"Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma","volume":"12","author":"Reustle","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Rausch, M., Rutz, A., Allard, P.-M., Delucinge-Vivier, C., Docquier, M., Dormond, O., Dyson, P., Wolfender, J.-L., and Nowak-Sliwinska, P. (2021). Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma. Cancers, 13.","DOI":"10.3390\/cancers13163978"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"F33","DOI":"10.1152\/ajprenal.00141.2021","article-title":"Three-dimensional coculture provides an improved in vitro model for papillary renal cell carcinoma","volume":"321","author":"Rosette","year":"2021","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1158\/1535-7163.MCT-19-0174","article-title":"Cabozantinib Reverses Renal Cell Carcinoma-mediated Osteoblast Inhibition in Three-dimensional Coculture In Vitro and Reduces Bone Osteolysis In Vivo","volume":"19","author":"Pan","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Grote, S., Traub, F., Mittelstaet, J., Seitz, C., Kaiser, A., Handgretinger, R., and Schleicher, S. (2021). Adapter Chimeric Antigen Receptor (AdCAR)-Engineered NK-92 Cells for the Multiplex Targeting of Bone Metastases. Cancers, 13.","DOI":"10.3390\/cancers13051124"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Belhabib, I., Zaghdoudi, S., Lac, C., Bousquet, C., and Jean, C. (2021). Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy. Cancers, 13.","DOI":"10.3390\/cancers13143466"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"119283","DOI":"10.1016\/j.biomaterials.2019.119283","article-title":"VEGF\u2014Supplemented extracellular matrix is sufficient to induce endothelial differentiation of human iPSC","volume":"216","author":"Ullah","year":"2019","journal-title":"Biomaterials"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Trivedi, P., Liu, R., Bi, H., Xu, C., Rosenholm, J.M., and \u00c5kerfelt, M. (2021). 3D Modeling of Epithelial Tumors-The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126225"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/pros.23985","article-title":"Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins","volume":"80","author":"Ojalill","year":"2020","journal-title":"Prostate"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/19336918.2015.1005463","article-title":"Tenascin-C and carcinoma cell invasion in oral and urinary bladder cancer","volume":"9","author":"Berndt","year":"2015","journal-title":"Cell Adh. Migr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1177\/1535370214560973","article-title":"Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography","volume":"240","author":"Iuliano","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"36128","DOI":"10.1038\/srep36128","article-title":"Linearized texture of three-dimensional extracellular matrix is mandatory for bladder cancer cell invasion","volume":"6","author":"Alfano","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.2147\/OTT.S194568","article-title":"Collagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer","volume":"12","author":"Zhu","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"BSR20194192","DOI":"10.1042\/BSR20194192","article-title":"Extracellular matrix-related genes play an important role in the progression of NMIBC to MIBC: A bioinformatics analysis study","volume":"40","author":"Zhang","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1007\/s11033-021-06440-8","article-title":"Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients","volume":"48","author":"Ghasemi","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Bond, K.H., Chiba, T., Wynne, K.P.H., Vary, C.P.H., Sims-Lucas, S., Coburn, J.M., and Oxburgh, L. (2021). The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth. Cancers, 13.","DOI":"10.3390\/cancers13235873"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Salo, T., Sutinen, M., Hoque Apu, E., Sundquist, E., Cervigne, N.K., De Oliveira, C.E., Akram, S.U., Ohlmeier, S., Suomi, F., and Eklund, L. (2015). A novel human leiomyoma tissue derived matrix for cell culture studies. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1944-z"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.yexcr.2018.06.037","article-title":"Desmoglein 3\u2014Influence on oral carcinoma cell migration and invasion","volume":"370","author":"Akram","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Merivaara, A., Koivunotko, E., Manninen, K., Kaseva, T., Monola, J., Salli, E., Koivuniemi, R., Savolainen, S., Valkonen, S., and Yliperttula, M. (2022). Stiffness-Controlled Hydrogels for 3D Cell Culture Models. Polymers, 14.","DOI":"10.3390\/polym14245530"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1186\/s40064-016-2629-z","article-title":"Impact of adjustable cryogel properties on the performance of prostate cancer cells in 3D","volume":"5","author":"Sturm","year":"2016","journal-title":"Springerplus"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/intbio\/zyac016","article-title":"A kidney proximal tubule model to evaluate effects of basement membrane stiffening on renal tubular epithelial cells","volume":"14","author":"Wang","year":"2022","journal-title":"Integr. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Millet, M., Bollmann, E., Goulet, C.R., Bernard, G., Chabaud, S., Huot, M., Pouliot, F., Bolduc, S., and Bordeleau, F. (2022). Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition. Cancers, 14.","DOI":"10.3390\/cancers14153810"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10616-018-0273-x","article-title":"Development of extracellular matrix supported 3D culture of renal cancer cells and renal cancer stem cells","volume":"71","author":"Brodaczewska","year":"2019","journal-title":"Cytotechnology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s11427-017-9178-y","article-title":"Hypoxia inducible factor (HIF) in the tumor microenvironment: Friend or foe","volume":"60","author":"Huang","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1901198","DOI":"10.1002\/advs.201901198","article-title":"Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC-Derived Embryonic Stage Mesodermal Precursor Cells","volume":"7","author":"Ullah","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.7150\/thno.38736","article-title":"Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Kolb, A.D., and Bussard, K.M. (2019). The Bone Extracellular Matrix as an Ideal Milieu for Cancer Cell Metastases. Cancers, 11.","DOI":"10.3390\/cancers11071020"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hughes, A.M., Kolb, A.D., Shupp, A.B., Shine, K.M., and Bussard, K.M. (2021). Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone-Tumor Niche. 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