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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:20:54Z","timestamp":1698913254462},"reference-count":132,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Three-dimensional tumor models have become established in both basic and clinical research. As multicellular systems consisting of tumor and tumor-associated cells, they can better represent tumor characteristics than monocellular 2D cultures. In this review, we highlight the potential applications of tumor spheroids and organoids in the field of urology. Further, we illustrate the generation and characteristics of standardized organoids as well as membrane-based 3D in vitro models in bladder cancer research. We discuss the technical aspects and review the initial successes of molecular analyses in the three major urologic tumor entities: urinary bladder carcinoma (BCa), prostate carcinoma (PCa), and renal cell carcinoma (RCC).<\/jats:p>","DOI":"10.3390\/ijms24076232","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T08:05:40Z","timestamp":1679904340000},"page":"6232","source":"Crossref","is-referenced-by-count":3,"title":["3D Tumor Models in Urology"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-2484-6994","authenticated-orcid":false,"given":"Jochen","family":"Neuhaus","sequence":"first","affiliation":[{"name":"Department of Urology, Research Laboratory, University Leipzig, D-04103 Leipzig, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0124-4878","authenticated-orcid":false,"given":"Anja","family":"Rabien","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Charit\u00e9platz 1, D-10117 Berlin, Germany"}]},{"given":"Annabell","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Department of Urology, Research Laboratory, University Leipzig, D-04103 Leipzig, Germany"}]},{"given":"Lisa","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Charit\u00e9platz 1, D-10117 Berlin, Germany"},{"name":"Institute of Environmental Science and Geography, University of Potsdam, D-14476 Potsdam, Germany"}]},{"given":"Mandy","family":"Berndt-Paetz","sequence":"additional","affiliation":[{"name":"Department of Urology, Research Laboratory, University Leipzig, D-04103 Leipzig, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1464-410X.2007.06795.x","article-title":"Differentiation potential of urothelium from patients with benign bladder dysfunction","volume":"99","author":"Southgate","year":"2007","journal-title":"BJU Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.eururo.2008.03.068","article-title":"Generation of a Functional, Differentiated Porcine Urothelial Tissue In Vitro","volume":"54","author":"Turner","year":"2008","journal-title":"Eur. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41598-018-19690-7","article-title":"A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection","volume":"8","author":"Horsley","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02512-5","article-title":"Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: An in vitro study","volume":"12","author":"Yuan","year":"2021","jo
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