uni-leipzig-open-access/json/ijc.34261

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T10:37:18Z","timestamp":1700822238563},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2151\u2010390873048"]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detection of tumor progression in patients with glioblastoma remains a major challenge. Extracellular vesicles (EVs) are potential biomarkers and can be detected in the blood of patients with glioblastoma. In our study, we evaluated the potential of serum\u2010derived EVs from glioblastoma patients to serve as biomarker for tumor progression. EVs from serum of glioblastoma patients and healthy volunteers were separated by size exclusion chromatography and ultracentrifugation. EV markers were defined by using a proximity\u2010extension assay and bead\u2010based flow cytometry. Tumor progression was defined according to modified RANO criteria. EVs from the serum of glioblastoma patients (n\u00a0=\u00a067) showed an upregulation of CD29, CD44, CD81, CD146, C1QA and histone H3 as compared to serum EVs from healthy volunteers (<jats:italic>P<\/jats:italic> value range: &lt;.0001 to .08). For two independent cohorts of glioblastoma patients, we noted upregulation of C1QA, CD44 and histone H3 upon tumor progression, but not in patients with stable disease. In a multivariable logistic regression analysis, a combination of CD29, CD44, CD81, C1QA and histone H3 correlated with RANO\u2010defined tumor progression with an AUC of 0.76. Measurement of CD29, CD44, CD81, C1QA and histone H3 in serum\u2010derived EVs of glioblastoma patients, along with standard MRI assessment, has the potential to improve detection of true tumor progression and thus could be a useful biomarker for clinical decision making.<\/jats:p>","DOI":"10.1002\/ijc.34261","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T12:35:09Z","timestamp":1661603709000},"page":"308-319","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-9651-1144","authenticated-orcid":false,"given":"Theophilos","family":"Tzaridis","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Clinical Pharmacology University Hospital, University of Bonn  Bonn Germany"},{"name":"Division of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Bonn University of Bonn  Bonn Germany"},{"name":"Tumor Initiation &amp; Maintenance Program Sanford Burnham Prebys Medical Discovery Institute  La Jolla California USA"}]},{"given":"Johannes","family":"Weller","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Bonn University of Bonn  Bonn Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-9168-9680","authenticated-orcid":false,"given":"Daniel","family":"Bachurski","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Cologne, Center for Molecular Medicine Cologne University of Cologne  Cologne Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-1161-1942","authenticated-orcid":false,"given":"Farhad","family":"Shakeri","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology, Institute for Genomic Statistics and Bioinformatics, Medical Faculty University of Bonn  Bonn Germany"}]},{"given":"Christina","family":"Schaub","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Bonn University of Bonn  Bonn Germany"}]},{"given":"Peter","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Neurology and Wilhelm Sander NeuroOncology Unit University Hospital Regensburg  Regensburg Germany"}]},{"given":"Andreas","family":"Buness","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology, Institute for Genomic Statistics and Bioinformatics, Medical Faculty University of Bonn  Bonn Germany"}]},{"given":"Uwe","family":"Schlegel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Knappschaftskrankenhaus, Ruhr\u2010University Bochum  Bochum Germany"}]},{"given":"Joachim\u2010Peter","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology University of Frankfurt  Frankfurt Germany"}]},{"given":"Clemens","family":"Seidel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Leipzig  Leipzig Germany"}]},{"given":"Roland","family":"Goldbrunner","sequence":"additional","affiliation":[{"name":"Center for Neurosurgery University of Cologne  Cologne Germany"}]},{"given":"Niklas","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Bonn University of Bonn  Bonn Germany"}]},{"given":"Robert J.","family":"Wechsler\u2010Reya","sequence":"additional","affiliation":[{"name":"Tumor Initiation &amp; Maintenance Program Sanford Burnham Prebys Medical Discovery Institute  La Jolla California USA"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Cologne, Center for Molecular Medicine Cologne University of Cologne  Cologne Germany"}]},{"given":"Bj\u00f6rn","family":"Scheffler","sequence":"additional","affiliation":[{"name":"DKFZ\u2010Division Translational Neurooncology at the West German Cancer Center and German Cancer Consortium, DKFZ Heidelberg &amp; Partner Site University Hospital Essen  Essen Germany"}]},{"given":"Martin","family":"Glas","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology and West German Cancer Center German Cancer Consortium, University Hospital Essen  Essen Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-4019-9328","authenticated-orcid":false,"given":"Lothar","family":"Haeberle","sequence":"additional","affiliation":[{"name":"Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen\u2010EMN Friedrich Alexander University of Erlangen\u2010Nuremberg  Nuremberg Germany"}]},{"given":"Ulrich","family":"Herrlinger","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen\u2010Bonn\u2010Cologne\u2010D\u00fcsseldorf, Partner Site Bonn University of Bonn  Bonn Germany"}]},{"given":"Christoph","family":"Coch","sequence":"additional","affiliation":[{"name":"Institute of 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