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Extracellular vesicles (EVs) are potential biomarkers and can be detected in the blood of patients with glioblastoma. In our study, we evaluated the potential of serum\u2010derived EVs from glioblastoma patients to serve as biomarker for tumor progression. EVs from serum of glioblastoma patients and healthy volunteers were separated by size exclusion chromatography and ultracentrifugation. EV markers were defined by using a proximity\u2010extension assay and bead\u2010based flow cytometry. Tumor progression was defined according to modified RANO criteria. EVs from the serum of glioblastoma patients (n\u00a0=\u00a067) showed an upregulation of CD29, CD44, CD81, CD146, C1QA and histone H3 as compared to serum EVs from healthy volunteers (<jats:italic>P<\/jats:italic> value range: <.0001 to .08). For two independent cohorts of glioblastoma patients, we noted upregulation of C1QA, CD44 and histone H3 upon tumor progression, but not in patients with stable disease. In a multivariable logistic regression analysis, a combination of CD29, CD44, CD81, C1QA and histone H3 correlated with RANO\u2010defined tumor progression with an AUC of 0.76. Measurement of CD29, CD44, CD81, C1QA and histone H3 in serum\u2010derived EVs of glioblastoma patients, along with standard MRI assessment, has the potential to improve detection of true tumor progression and thus could be a useful biomarker for clinical decision making.<\/jats:p>","DOI":"10.1002\/ijc.34261","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T12:35:09Z","timestamp":1661603709000},"page":"308-319","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-9651-1144","authenticated-orcid":false,"given":"Theophilos","family":"Tzaridis","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Clinical Pharmacology University Hospital, University of Bonn Bonn 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