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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T13:21:21Z","timestamp":1706016081745},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["S\/04\/21"]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to compare outcomes after transcatheter mitral valve replacement (TMVR) and mitral valve transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) for the treatment of secondary mitral regurgitation (SMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The CHOICE\u2010MI registry included 262 patients with SMR treated with TMVR between 2014 and 2022. The EuroSMR registry included 1065 patients with SMR treated with M\u2010TEER between 2014 and 2019. Propensity score (PS) matching was performed for 12 demographic, clinical and echocardiographic parameters. Echocardiographic, functional and clinical outcomes out to 1\u2009year were compared in the matched cohorts. After PS matching, 235 TMVR patients (75.5\u2009years [70.0, 80.0], 60.2% male, EuroSCORE II 6.3% [interquartile range 3.8, 12.4]) were compared to 411\u2009M\u2010TEER patients (76.7\u2009years [70.1, 80.5], 59.0% male, EuroSCORE II 6.7% [3.9, 12.4]). All\u2010cause mortality was 6.8% after TMVR and 3.8% after M\u2010TEER at 30\u2009days (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.11), and 25.8% after TMVR and 18.9% after M\u2010TEER at 1\u00a0year (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.056). No differences in mortality after 1\u00a0year were found between both groups in a 30\u2010day landmark analysis (TMVR: 20.4%, M\u2010TEER: 15.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.21). Compared to M\u2010TEER, TMVR resulted in more effective mitral regurgitation (MR) reduction (residual MR \u22641+ at discharge for TMVR vs. M\u2010TEER: 95.8% vs. 68.8%, <jats:italic>p<\/jats:italic>\u2009<\u20090.001), and superior symptomatic improvement (New York Heart Association class \u2264II at 1\u00a0year: 77.8% vs. 64.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this PS\u2010matched comparison between TMVR and M\u2010TEER in patients with severe SMR, TMVR was associated with superior reduction of MR and superior symptomatic improvement. While post\u2010procedural mortality tended to be higher after TMVR, no significant differences in mortality were found beyond 30\u2009days.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejhf.2797","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T11:55:35Z","timestamp":1678276535000},"page":"399-410","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcatheter mitral valve replacement or repair for secondary mitral regurgitation: a propensity score\u2010matched analysis"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-5752-4951","authenticated-orcid":false,"given":"Sebastian","family":"Ludwig","sequence":"first","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"},{"name":"Cardiovascular Research Foundation New York NY USA"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}]},{"given":"Walid Ben","family":"Ali","sequence":"additional","affiliation":[{"name":"Structural Valve Program, Montreal Heart Institute Montr\u00e9al QC Canada"}]},{"given":"Jessica","family":"Weimann","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center University of Cologne Cologne Germany"}]},{"given":"Alison","family":"Duncan","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London UK"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital Vancouver BC Canada"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kardiologie Bern Switzerland"}]},{"given":"Mathias","family":"Orban","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Klinikum der Universit\u00e4t M\u00fcnchen Munich Germany"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department University of Pisa Pisa Italy"}]},{"given":"Augustin","family":"Coisne","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY USA"},{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID Lille France"}]},{"given":"Nicole","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, European Hospital Georges Pompidou, and Paris Cardiovascular Research Center Paris France"}]},{"given":"Andrea","family":"Scotti","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Center for Heart and Vascular Care Montefiore Medical Center New York NY USA"}]},{"given":"Lars","family":"Sondergaard","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy"}]},{"given":"David W.M.","family":"Muller","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Sydney NSW Australia"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Herzzentrum Brandenburg Medizinische Hochschule Brandenburg Theodor Fontane Bernau Germany"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Ospedale San Raffaele Milan Italy"}]},{"given":"Bruno","family":"Melica","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Vila Nova de Gaia Espinho Portugal"}]},{"given":"Damiano","family":"Regazzoli","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital Milan Italy"}]},{"given":"Andrea","family":"Garatti","sequence":"additional","affiliation":[{"name":"IRCCS Policlinico San Donato Milan Italy"}]},{"given":"Tobias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Medical Clinic II University Heart Center L\u00fcbeck L\u00fcbeck Germany"}]},{"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}]},{"given":"Gry","family":"Dahle","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"HerzZentrum Hirslanden Z\u00fcrich Z\u00fcrich Switzerland"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Heart Center Bonn Bonn Germany"}]},{"given":"Nicolas","family":"Dumonteil","sequence":"additional","affiliation":[{"name":"Groupe CardioVasculaire Interventionnel, Clinique Pasteur Toulouse Toulouse France"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"Frankfurt University Hospital Frankfurt Germany"}]},{"given":"Michele","family":"Flagiello","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Louis Pradel Cardiologic Hospital Lyon France"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"German Heart Institute Berlin Berlin Germany"}]},{"given":"Neil","family":"Fam","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital University of Toronto Toronto ON Canada"}]},{"given":"Hendrik","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery German Heart Center Munich Munich Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center Munich INSURE\u00a0\u2013\u00a0Institute for Translational Cardiac Surgery Munich Germany"}]},{"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Interventional and General Cardiology, Heart\u2010 and Diabetes Center Nordrhine\u2010Westphalia, Bad Oeynhausen Ruhr University Bochum Bochum Germany"}]},{"given":"Moritz C.","family":"Wyler von Ballmoos","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital Houston TX USA"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy"}]},{"given":"Simon","family":"Redwood","sequence":"additional","affiliation":[{"name":"St. Thomas' Hospital London UK"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY USA"}]},{"given":"Gilbert H.L.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mount Sinai Health System New York NY USA"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Center for Heart and Vascular Care Montefiore Medical Center New York NY USA"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Heart Valve Center and Heart and Vascular Center Universit\u00e4tsmedizin Mainz Mainz Germany"}]},{"given":"Thomas","family":"Modine","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Bordeaux France"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Klinikum der Universit\u00e4t M\u00fcnchen Munich Germany"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart and Vascular Center Hamburg Hamburg Germany"}]},{"name":"on behalf of the CHOICE\u2010MI and the EuroSMR Investigators (see online Appendix S1)","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx402"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab086"},{"key":"e_1_2_8_7_1","first-page":"E72","article-title":"2020 ACC\/AHA Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto 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