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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T13:21:21Z","timestamp":1706016081745},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["S\/04\/21"]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to compare outcomes after transcatheter mitral valve replacement (TMVR) and mitral valve transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) for the treatment of secondary mitral regurgitation (SMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The CHOICE\u2010MI registry included 262 patients with SMR treated with TMVR between 2014 and 2022. The EuroSMR registry included 1065 patients with SMR treated with M\u2010TEER between 2014 and 2019. Propensity score (PS) matching was performed for 12 demographic, clinical and echocardiographic parameters. Echocardiographic, functional and clinical outcomes out to 1\u2009year were compared in the matched cohorts. After PS matching, 235 TMVR patients (75.5\u2009years [70.0, 80.0], 60.2% male, EuroSCORE II 6.3% [interquartile range 3.8, 12.4]) were compared to 411\u2009M\u2010TEER patients (76.7\u2009years [70.1, 80.5], 59.0% male, EuroSCORE II 6.7% [3.9, 12.4]). All\u2010cause mortality was 6.8% after TMVR and 3.8% after M\u2010TEER at 30\u2009days (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.11), and 25.8% after TMVR and 18.9% after M\u2010TEER at 1\u00a0year (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.056). No differences in mortality after 1\u00a0year were found between both groups in a 30\u2010day landmark analysis (TMVR: 20.4%, M\u2010TEER: 15.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.21). Compared to M\u2010TEER, TMVR resulted in more effective mitral regurgitation (MR) reduction (residual MR \u22641+ at discharge for TMVR vs. M\u2010TEER: 95.8% vs. 68.8%, <jats:italic>p<\/jats:italic>\u2009<\u20090.001), and superior symptomatic improvement (New York Heart Association class \u2264II at 1\u00a0year: 77.8% vs. 64.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this PS\u2010matched comparison between TMVR and M\u2010TEER in patients with severe SMR, TMVR was associated with superior reduction of MR and superior symptomatic improvement. While post\u2010procedural mortality tended to be higher after TMVR, no significant differences in mortality were found beyond 30\u2009days.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejhf.2797","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T11:55:35Z","timestamp":1678276535000},"page":"399-410","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcatheter mitral valve replacement or repair for secondary mitral regurgitation: a propensity score\u2010matched analysis"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-5752-4951","authenticated-orcid":false,"given":"Sebastian","family":"Ludwig","sequence":"first","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"},{"name":"Cardiovascular Research Foundation New York NY USA"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hea
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