uni-leipzig-open-access/json/s41431-022-01257-w

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Association between <jats:italic>FANCM<\/jats:italic> missense variants (MVs) and breast cancer risk has been postulated. In this study, we further used the BRIDGES study to test 689 <jats:italic>FANCM<\/jats:italic> MVs for association with breast cancer risk, overall and in ER-negative and TNBC subtypes, in 39,885 cases (7566 selected for family history) and 35,271 controls of European ancestry. Sixteen common MVs were tested individually; the remaining rare 673 MVs were tested by burden analyses considering their position and pathogenicity score. We also conducted a meta-analysis of our results and those from published studies. We did not find evidence for association for any of the 16 variants individually tested. The rare MVs were significantly associated with increased risk of ER-negative breast cancer by burden analysis comparing familial cases to controls (OR\u2009=\u20091.48; 95% CI 1.07\u20132.04; <jats:italic>P<\/jats:italic>\u2009=\u20090.017). Higher ORs were found for the subgroup of MVs located in functional domains or predicted to be pathogenic. The meta-analysis indicated that <jats:italic>FANCM<\/jats:italic> MVs overall are associated with breast cancer risk (OR\u2009=\u20091.22; 95% CI 1.08\u20131.38; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Our results support the definition from previous analyses of <jats:italic>FANCM<\/jats:italic> as a moderate-risk breast cancer gene and provide evidence that <jats:italic>FANCM<\/jats:italic> MVs could be low\/moderate risk factors for ER-negative and TNBC subtypes. Further genetic and functional analyses are necessary to clarify better the increased risks due to <jats:italic>FANCM<\/jats:italic> MVs.<\/jats:p>","DOI":"10.1038\/s41431-022-01257-w","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:03:44Z","timestamp":1674806624000},"page":"578-587","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-0740-1363","authenticated-orcid":false,"given":"Gisella","family":"Figlioli","sequence":"first","affiliation":[]},{"given":"Amandine","family":"Billaud","sequence":"additional","affiliation":[]},{"given":"Thomas U.","family":"Ahearn","sequence":"additional","affiliation":[]},{"given":"Natalia N.","family":"Antonenkova","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8808-6667","authenticated-orcid":false,"given":"Heiko","family":"Becher","sequence":"additional","affiliation":[]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9714-104X","authenticated-orcid":false,"given":"Sabine","family":"Behrens","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Benitez","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Bermisheva","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-7935-5933","authenticated-orcid":false,"given":"Marinus J.","family":"Blok","sequence":"additional","affiliation":[]},{"given":"Natalia V.","family":"Bogdanova","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0003-3589-2128","authenticated-orcid":false,"given":"Bernardo","family":"Bonanni","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Burwinkel","sequence":"additional","affiliation":[]},{"given":"Nicola J.","family":"Camp","sequence":"additional","affiliation":[]},{"given":"Archie","family":"Campbell","sequence":"additional","affiliation":[]},{"given":"Jose E.","family":"Castelao","sequence":"additional","affiliation":[]},{"given":"Melissa H.","family":"Cessna","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-2324-3393","authenticated-orcid":false,"given":"Stephen J.","family":"Chanock","sequence":"additional","affiliation":[]},{"given":"Kristine K.","family":"Sahlberg","sequence":"additional","affiliation":[]},{"given":"Anne-Lise","family":"B\u00f8rresen-Dale","sequence":"additional","affiliation":[]},{"given":"Inger Torhild","family":"Gram","sequence":"additional","affiliation":[]},{"given":"Karina Standahl","family":"Olsen","sequence":"additional","affiliation":[]},{"given":"Olav","family":"Engebr\u00e5ten","sequence":"additional","affiliation":[]},{"given":"Bj\u00f8rn","family":"Naume","sequence":"additional","affiliation":[]},{"given":"J\u00fcrgen","family":"Geisler","sequence":"additional","affiliation":[]},{"given":"Tone F.","family":"Bathen","sequence":"additional","affiliation":[]},{"given":"Elin","family":"Borgen","sequence":"additional","affiliation":[]},{"given":"Britt","family":"Fritzman","sequence":"additional","affiliation":[]},{"given":"\u00d8ystein","family":"Garred","sequence":"additional","affiliation":[]},{"given":"Gry Aarum","family":"Geitvik","sequence":"additional","affiliation":[]},{"given":"Solveig","family":"Hofvind","sequence":"additional","affiliation":[]},{"given":"Anita","family":"Langer\u00f8d","sequence":"additional","affiliation":[]},{"given":"Ole Christian","family":"Lingj\u00e6rde","sequence":"additional","affiliation":[]},{"given":"Gunhild Mari","family":"M\u00e6landsmo","sequence":"additional","affiliation":[]},{"given":"Hege G.","family":"Russnes","sequence":"additional","affiliation":[]},{"given":"Helle Kristine","family":"Skjerven","sequence":"additional","affiliation":[]},{"given":"Therese","family":"S\u00f8rlie","sequence":"additional","affiliation":[]},{"given":"Grethe I. 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