uni-leipzig-open-access/json/jce.15714

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:42:01Z","timestamp":1692506521380},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal denervation (RDN) can reduce cardiac sympathetic activity maintained by arterial hypertension (aHT). Its potential antiarrhythmic effect on rhythm outcome in patients with multi\u2010drug resistant aHT undergoing catheter ablation for atrial fibrillation (AF) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The RDN+AF study was a prospective, randomized, two\u2010center trial. Patients with paroxysmal or persistent AF and uncontrolled aHT (mean systolic 24\u2010h ambulatory BP &gt; 135\u2009mmHg) despite taking at least three antihypertensive drugs were enrolled. Patients were 1:2 randomized to either RDN+AF ablation or AF\u2010only ablation. Primary endpoint was freedom from any AF episode\u2009&gt;\u20092\u2009min at 12 months assessed by implantable loop recorder (ILR) or 7d\u2010holter electrocardiogram. Secondary endpoints included rhythm outcome at 24 months, blood pressure control, periprocedural complications, and renovascular safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study randomized 61 patients (mean age 65\u2009\u00b1\u20099 years, 53% men). At 12 months, RDN+AF patients tended to have a greater decrease in ambulatory BPs but did not reach statistical significance. No differences in rhythm outcome were observed. Freedom from AF recurrence in the RDN+AF and AF\u2010only group measured 61% versus 53% <jats:italic>p<\/jats:italic>\u2009=\u2009.622 at 12 months and 39% versus 47% <jats:italic>p<\/jats:italic>\u2009=\u2009.927 at 24 months, respectively. Periprocedural complications occurred in 9\/61 patients (15%). No patient died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with multidrug\u2010resistant aHT and paroxysmal or persistent AF, concomitant RDN+AF ablation was not associated with better blood pressure control or rhythm outcome in comparison to AF\u2010only ablation and medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15714","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T12:55:12Z","timestamp":1666184112000},"page":"44-53","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of concomitant Renal DeNervation and cardiac ablation on Atrial Fibrillation recurrence \u2013 RDN+AF study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-6881-871X","authenticated-orcid":false,"given":"Bettina","family":"Kirstein","sequence":"first","affiliation":[{"name":"Department of Rhythmology University Heart Center L\u00fcbeck, University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"},{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Jakub","family":"Tomala","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Julia","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Stefan","family":"Ulbrich","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Liying","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Judith","family":"Piorkowski","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"},{"name":"Steinbeis Research Center, \u201cRhythm &amp; Heart\u201d  Dresden Germany"}]},{"given":"Anastasia","family":"Hankel","sequence":"additional","affiliation":[{"name":"Steinbeis Research Center, \u201cRhythm &amp; Heart\u201d  Dresden Germany"}]},{"given":"Yan","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Thomas","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Utz","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig University  Leipzig Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8110-6290","authenticated-orcid":false,"given":"Christopher","family":"Piorkowski","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Dresden, TU Dresden, Faculty of Medicine Carl Gustav Carus  Dresden Germany"},{"name":"Steinbeis Research Center, \u201cRhythm &amp; 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