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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T11:59:52Z","timestamp":1704715192889},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research"},{"name":"German Frontotemporal Lobar Dementia Consortium","award":["FKZ O1GI1007A"]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SCHR 774\/5-1"]},{"name":"eHealthSax Initiative of the S\u00e4chsische Aufbaubank"},{"name":"Max Planck Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Understanding the relationships between brain structure and language behaviour in primary progressive aphasia provides crucial information about these diseases\u2019 pathomechanisms. However, previous investigations have been limited from providing a statistically reliable view of broad language abilities by sample size, variant focus and task focus. In this study, the authors aimed to determine the relationship between brain structure and language behaviour in primary progressive aphasia, to determine the degree to which task-associated regions were atrophied across disease variants and to determine the degree to which task-related atrophy overlaps across disease variants. Participants were 118 primary progressive aphasia patients and 61 healthy, age-matched controls tested from 2011 to 2018 in the German Consortium for Frontotemporal Lobar Degeneration cohort. Diagnosis of primary progressive aphasia required progressive deterioration of mainly speech and language for \u2265 2 years, and variant was diagnosed by the criteria of Gorno-Tempini et al. (Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014). Twenty-one participants not fulfilling a specific subtype were classified as mixed-variant and excluded. Language tasks of interest included the Boston naming test, a German adaptation of the Repeat and Point task, phonemic and category fluency tasks and the reading\/writing subtest of the Aachen Aphasia Test. Brain structure was measured by cortical thickness. We observed networks of language task-associated temporal, frontal and parietal cortex. Overlapping task-associated atrophy was observed in the left lateral, ventral and medial temporal lobes, middle and superior frontal gyri, supramarginal gyrus and insula. Some regions, primarily in the perisylvian region, were associated with language behaviour despite showing no significant atrophy. The results crucially extend less powerful studies associating brain and language measures in primary progressive aphasia. Cross-variant atrophy in task-associated regions suggests partially shared underlying deficits, whereas unique atrophy reinforces variant-specific deficits. Language task-related regions that are not obviously atrophied suggest regions of future network disruption and encourage understanding of task deficits beyond clearly atrophied cortex. These results may pave the way for new treatment approaches.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad076","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:46:36Z","timestamp":1678927596000},"source":"Crossref","is-referenced-by-count":3,"title":["Structural correlates of language processing in primary progressive aphasia"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-3969-4612","authenticated-orcid":false,"given":"Curtiss A","family":"Chapman","sequence":"first","affiliation":[{"name":"Lise Meitner Group for Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig 04103 , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0617-0097","authenticated-orcid":false,"given":"Maryna","family":"Polyakova","sequence":"additional","affiliation":[{"name":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig 04103 , Germany"},{"name":"Department of Neurology, University of Leipzig Medical Center , Leipzig 04103 , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-9613-0552","authenticated-orcid":false,"given":"Karsten","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig 04103 , Germany"}]},{"given":"Christopher","family":"Weise","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center , Leipzig 04103 , Germany"},{"name":"Department of Neurology, University of Halle Medical Center , Halle 06120 , Germany"}]},{"given":"Klaus","family":"Fassbender","sequence":"additional","affiliation":[{"name":"Department of Neurology, Saarland University Hospital , Homburg 66421 , Germany"}]},{"given":"Klaus","family":"Fliessbach","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Bonn , Bonn 53127 , Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) , Germany"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Erlangen , Erlangen 91054 , Germany"}]},{"given":"Martin","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital W\u00fcrzburg , W\u00fcrzburg 97080 , Germany"}]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 89081 , Germany"}]},{"given":"Albert","family":"Ludolph","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 89081 , Germany"}]},{"given":"Johannes","family":"Prudlo","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) , Germany"},{"name":"Department of Neurology, University Medicine Rostock , Rostock 18051 , Germany"}]},{"given":"Anja","family":"Staiger","sequence":"additional","affiliation":[{"name":"Clinical Neuropsychology Research Group, Institute of Phonetics and Speech Processing, Ludwig-Maximilians-University Munich , Munich 80539 , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) , Germany"},{"name":"Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research , T\u00fcbingen 72076 , Germany"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) , Germany"},{"name":"Department of Psychiatry and Psychotherapy, Medical University G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"}]},{"given":"Lina","family":"Riedl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Technical University of Munich , Munich 80333 , Germany"}]},{"given":"Janine","family":"Diehl-Schmid","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Technical University of Munich , Munich 80333 , Germany"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 89081 , Germany"}]},{"given":"Adrian","family":"Danek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University Munich , Munich 80539 , Germany"}]},{"given":"Annerose","family":"Engel","sequence":"additional","affiliation":[]},{"given":"Gerdi","family":"Pf\u00fcller","sequence":"additional","affiliation":[]},{"given":"Dani\u00e9le","family":"Pino","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Regenbrecht","sequence":"additional","affiliation":[]},{"given":"Angelika","family":"Th\u00f6ne-Otto","sequence":"additional","affiliation":[]},{"given":"Timo","family":"Oberstein","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Landwehrmeyer","sequence":"additional","affiliation":[]},{"given":"Jolina","family":"Lombardi","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"Semler","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8084-1330","authenticated-orcid":false,"given":"Gesa","family":"Hartwigsen","sequence":"additional","affiliation":[{"name":"Lise 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