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This review focuses on 10 novel key aspects of the current guideline: As new aspects, public basic life support and access to defibrillators are guideline topics. Recommendations for the diagnostic evaluation of patients with ventricular arrhythmias are structured according to frequently encountered clinical scenarios. Management of electrical storm has become a new focus. In addition, genetic testing and cardiac magnetic resonance imaging significantly gained relevance for both diagnostic evaluation and risk stratification. New algorithms for antiarrhythmic drug therapy aim at improving safe drug use. The new recommendations reflect increasing relevance of catheter ablation of ventricular arrhythmias, especially in patients without structural heart disease or stable coronary artery disease with only mildly impaired ejection fraction and haemodynamically tolerated ventricular tachycardias. Regarding sudden cardiac death risk stratification, risk calculators for laminopathies, and long QT syndrome are now considered besides the already established risk calculator for hypertrophic cardiomyopathy. Generally, \u2018new\u2019 risk markers beyond left ventricular ejection fraction are increasingly considered for recommendations on primary preventive implantable cardioverter defibrillator therapy. Furthermore, new recommendations for diagnosis of Brugada syndrome and management of primary electrical disease have been included. With many comprehensive flowcharts and practical algorithms, the new guideline takes a step towards a user-oriented reference book.<\/jats:p>","DOI":"10.1093\/europace\/euad091","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:34:50Z","timestamp":1682580890000},"source":"Crossref","is-referenced-by-count":14,"title":["Spotlight on the 2022 ESC guideline management of ventricular arrhythmias and prevention of sudden cardiac death: 10 novel key aspects"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-9812-5519","authenticated-orcid":false,"given":"Hilke","family":"K\u00f6nemann","sequence":"first","affiliation":[{"name":"Department of Cardiology II: Electrophysiology, University Hospital M\u00fcnster , Albert-Schweitzer Campus 1, 48149 M\u00fcnster , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0323-4956","authenticated-orcid":false,"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology, Heart Center Leipzig at University of Leipzig , Leipzig , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-1737-1903","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Merino","sequence":"additional","affiliation":[{"name":"Cardiology Department, La Paz University Hospital , Madrid , Spain"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-8428-7050","authenticated-orcid":false,"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Basel , Basel , Switzerland"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-6645-082X","authenticated-orcid":false,"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical 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