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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:13:43Z","timestamp":1697458423878},"reference-count":21,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Measuring C-reactive protein (CRP) in serum is a useful surrogate marker for assessing disease progression and treatment response in dogs with autoinflammatory diseases. Affected dogs often receive high-dose glucocorticoid treatment, but the effect of such treatment alone on serum CRP concentrations is unknown. We evaluated serum CRP concentrations via immunoassay (sandwich enzyme-linked immunosorbent assay and particle-enhanced turbidimetric immunoassay) in 12 healthy beagle dogs administered high-dose hydrocortisone (8 mg\/kg q12 h) per os vs. placebo over 28 days (days 0, 1, 5, and 28) in a randomized parallel study design. Serum CRP concentrations slightly decreased during treatment or placebo but without a significant association with hydrocortisone administration (p = 0.761). Compared to baseline, serum CRP concentrations were decreased by >2.7-fold (minimum critical difference) in three hydrocortisone-treated dogs and two dogs in the placebo group on day 28, whereas an increase to >2.7-fold was seen in one dog receiving placebo. These results suggest a lack of confounding effects of high-dose hydrocortisone administration on serum CRP concentrations in healthy dogs. This might also hold in dogs with autoinflammatory conditions and\/or administration of other high-dose corticosteroids, suggesting that CRP presents a suitable biomarker to monitor inflammatory disease processes. However, this needs confirmation by further studies evaluating corticosteroid-induced cellular (e.g., hepatic) transcriptome and proteome changes.<\/jats:p>","DOI":"10.3390\/vetsci10100620","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T14:47:32Z","timestamp":1697381252000},"page":"620","source":"Crossref","is-referenced-by-count":0,"title":["High-Dose Hydrocortisone Treatment Does Not Affect Serum C-Reactive Protein (CRP) Concentrations in Healthy Dogs"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-3485-5157","authenticated-orcid":false,"given":"Romy M.","family":"Heilmann","sequence":"first","affiliation":[{"name":"Department for Small Animals, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 23, DE-04103 Leipzig, Germany"}]},{"given":"Niels","family":"Gr\u00fctzner","sequence":"additional","affiliation":[{"name":"Ruminant and Swine Clinic, Free University of Berlin, K\u00f6nigsweg 65, DE-14163 Berlin, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9492-3484","authenticated-orcid":false,"given":"Peter H.","family":"Kook","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland"}]},{"ORCID":"http:\/\/orcid.org\/0009-0000-7205-5893","authenticated-orcid":false,"given":"Stefan","family":"Schellenberg","sequence":"additional","affiliation":[{"name":"Small Animal Specialty Center Aarau West, Muhenstrasse 56, CH-5036 Oberentfelden, Switzerland"}]},{"given":"Jan S.","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, TAMU 4474, College Station, TX 77845, USA"}]},{"given":"Joerg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, TAMU 4474, College Station, TX 77845, USA"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/vcp.13100","article-title":"Measurement and clinical applications of C-reactive protein in gastrointestinal diseases of dogs","volume":"50","author":"Covin","year":"2022","journal-title":"Vet. 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Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/vcp.12150","article-title":"Validation of a commercially available automated canine-specific immunoturbidimetric method for measuring canine C-reactive protein","volume":"43","author":"Hagman","year":"2014","journal-title":"Vet. Clin. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1939-165X.2011.00339.x","article-title":"Evaluation of a point-of-care test for canine C-reactive protein","volume":"40","author":"Plickert","year":"2011","journal-title":"Vet. Clin. Pathol."},{"key":"ref_13","first-page":"791","article-title":"Assessment of stability and determination of a reference range for canine C-reactive protein in serum","volume":"20","author":"Berghoff","year":"2006","journal-title":"J. Vet. Intern. 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Abstr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/jcph.1914","article-title":"Influence of prednisone on inflammatory biomarkers in community-acquired pneumonia: Secondary analysis of a randomized trial","volume":"61","author":"Raess","year":"2021","journal-title":"J. Clin. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1538\/expanim.52.387","article-title":"Determination of serum C-reactive protein (CRP) in healthy beagle dogs of various ages and pregnant beagle dogs","volume":"52","author":"Kuribayashi","year":"2003","journal-title":"Exp. 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