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Dabei wird die Leber transarteriell mit Melphalan perfundiert und aufges\u00e4ttigt (Chemosaturation), mit dem Ziel, die Lebertumoren selektiv und ohne dessen systemische zytotoxische Eigenschaften zu behandeln. \u00dcber einen Extrakorporalkreislauf und eine Ballonokklusion der V.\u00a0cava inferior wird das ven\u00f6se hepatische Blut h\u00e4mofiltriert und ven\u00f6s zur\u00fcckgeleitet. Verfahrensbedingt kommt es dabei zu einer ausgepr\u00e4gten Kreislaufdepression und einer St\u00f6rung der plasmatischen Gerinnung. In diesem Artikel wird das an\u00e4sthesiologische und postinterventionelle Management bei Patienten mit PHMP beschrieben und auf Fallstricke und Besonderheiten hingewiesen.<\/jats:p>","DOI":"10.1007\/s00101-022-01235-3","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T18:02:36Z","timestamp":1670436156000},"page":"113-120","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An\u00e4sthesiologisches und postinterventionelles Management bei perkutaner hepatischer Melphalanperfusion (Chemosaturation)"],"prefix":"10.1007","volume":"72","author":[{"given":"Peter","family":"Kliem","sequence":"first","affiliation":[]},{"given":"Sebastian","family":"Ebel","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Werdehausen","sequence":"additional","affiliation":[]},{"given":"Felix","family":"Girrbach","sequence":"additional","affiliation":[]},{"given":"Denis","family":"B\u00f6semann","sequence":"additional","affiliation":[]},{"given":"Florian","family":"van B\u00f6mmel","sequence":"additional","affiliation":[]},{"given":"Timm","family":"Denecke","sequence":"additional","affiliation":[]},{"given":"Sebastian","family":"Stehr","sequence":"additional","affiliation":[]},{"given":"Manuel F.","family":"Struck","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"issue":"11","key":"1235_CR1","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1007\/s00101-016-0226-8","volume":"65","author":"J Abram","year":"2016","unstructured":"Abram\u00a0J, Klocker\u00a0J, Innerhofer-Pompernigg\u00a0N et al (2016) Verletzungen herznaher Gef\u00e4\u00dfe durch zentralven\u00f6se Katheter. 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