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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T10:34:27Z","timestamp":1695292467820},"reference-count":86,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Regensburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This systematic review focuses on the different study protocols on CoQ10 as an adjunct in non-surgical periodontitis therapy. The study protocol was developed following PRISMA guidelines and was registered in PROSPERO (CRD42021156887). A sensitive search up to January 2022 considered MEDLINE via PubMed and Web of Science, Embase, Web of Science Core Collection via Web of Science, Google Scholar, Cochrane CENTRAL, WHO (ICTRP), ClinicalTrials.gov, and grey literature. Randomized controlled (SRP with\/without placebo) clinical trials (RCTs) on all types of CoQ10 administration were included. The primary outcome was probing pocket depth (PPD). Secondary outcomes were bleeding on probing, clinical attachment loss, and gingival and plaque indices. Twelve RCTs with local and five with systemic CoQ10 administration were included. The study protocols were heterogeneous. Local CoQ10 administration was performed once or several times in a period up to 15 days. Systemic CoQ10 was applied twice or three times daily for six weeks up to four months. The reporting quality was low, including missing information about CoQ10 doses. Risk of bias was high or unclear. About half of the studies reported significant group differences for PPD. Until now, no statement on the effectiveness of CoQ10 in non-surgical periodontitis therapy is possible. Further high-quality RCTs are necessary and should consider the protocol recommendations of this review.<\/jats:p>","DOI":"10.3390\/nu15071585","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:43:03Z","timestamp":1679661783000},"page":"1585","source":"Crossref","is-referenced-by-count":1,"title":["Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-0112-7631","authenticated-orcid":false,"given":"Cordula Leonie","family":"Merle","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry, UKR University Hospital Regensburg, 93053 Regensburg, Germany"},{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}]},{"given":"Carina","family":"Lenzen","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-6602-377X","authenticated-orcid":false,"given":"Gerhard","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9810-2368","authenticated-orcid":false,"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1902\/annals.1999.4.1.32","article-title":"Periodontitis","volume":"4","author":"Flemmig","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: An introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol. 2000"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mam.2017.04.006","article-title":"Pro-resolving mediators in the regulation of periodontal disease","volume":"58","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: From microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1034\/j.1600-0757.2002.280103.x","article-title":"Antimicrobial effects of mechanical debridement","volume":"28","author":"Petersilka","year":"2002","journal-title":"Periodontol. 2000"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1034\/j.1600-051X.29.s3.3.x","article-title":"A systematic review on the clinical efficacy of subgingival debridement in the treatment of chronic periodontitis","volume":"29","author":"Timmerman","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/1678-775720140259","article-title":"Host response mechanisms in periodontal diseases","volume":"23","author":"Silva","year":"2015","journal-title":"J. Appl. Oral Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Papantonopoulos, G., Delatola, C., Takahashi, K., Laine, M.L., and Loos, B.G. (2019). Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224615"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jcpe.12026","article-title":"A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis","volume":"40","author":"Figuero","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/jre.12821","article-title":"Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta-analysis","volume":"56","author":"Sgolastra","year":"2021","journal-title":"J. Periodontal Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zandbergen, D., Slot, D.E., Niederman, R., and der Weijden, A.V. (2016). The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =A systematic review=. BMC Oral Health, 16.","DOI":"10.1186\/s12903-015-0123-6"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/jcpe.13230","article-title":"Adjunctive effect of locally delivered antimicrobials in periodontitis therapy: A systematic review and meta-analysis","volume":"47","author":"Herrera","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhao, H., Hu, J., and Zhao, L. (2020). Adjunctive subgingival application of Chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: A systematic review and meta-analysis. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-1021-0"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sdentj.2020.11.002","article-title":"Use of chlorhexidine chip after scaling and root planning on periodontal disease: A systematic review and meta-analysis","volume":"33","author":"Rosa","year":"2021","journal-title":"Saudi Dent. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jcpe.13264","article-title":"Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis","volume":"47","author":"Teughels","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jdent.2016.03.002","article-title":"Probiotics for managing caries and periodontitis: Systematic review and meta-analysis","volume":"48","author":"Gruner","year":"2016","journal-title":"J. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101547","DOI":"10.1016\/j.jebdp.2021.101547","article-title":"Clinical efficacy of probiotics as an adjunctive therapy to scaling and root planning in the management of periodontitis: A Systematic Review and Meta-Analysis of randomized controlled trails","volume":"21","author":"Hu","year":"2021","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101710","DOI":"10.1016\/j.jebdp.2022.101710","article-title":"The Effect of Coenzyme Q10 on periodontitis: A Systematic Review and Meta-analysis of Clinical Trials: In-press","volume":"22","author":"Rasoolzadeh","year":"2022","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000360101","article-title":"Coenzyme q10 therapy","volume":"5","author":"Cordero","year":"2014","journal-title":"Mol. Syndromol."},{"key":"ref_20","first-page":"21","article-title":"Coenzyme Q10 and periodontal health: A review","volume":"3","author":"Soni","year":"2012","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/0253-7613.71884","article-title":"Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases","volume":"42","author":"Prakash","year":"2010","journal-title":"Indian J. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/15216540701545991","article-title":"Functional connections and pathways of coenzyme Q10-inducible genes: An in-silico study","volume":"59","author":"Schmelzer","year":"2007","journal-title":"IUBMB Life"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3164\/jcbn.08-182","article-title":"In Vitro Effects of the Reduced Form of Coenzyme Q10 on Secretion Levels of TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1","volume":"44","author":"Schmelzer","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1073\/pnas.68.10.2332","article-title":"Deficiency of coenzyme Q 10 in gingival tissue from patients with periodontal disease","volume":"68","author":"Littarru","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","first-page":"729","article-title":"Bioenergetics in clinical medicine. IX. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease","volume":"14","author":"Hansen","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.71.4.1456","article-title":"Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10","volume":"71","author":"Nakamura","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","first-page":"111","article-title":"Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy","volume":"12","author":"Wilkinson","year":"1975","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_28","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2022, April 05). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2. Available online: https:\/\/training.cochrane.org\/handbook."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_30","unstructured":"Centre for Reviews and Dissemination University of York (2021, February 20). PROSPERO: International Prospective Register of Systematic Reviews. Available online: https:\/\/www.crd.york.ac.uk\/prospero\/."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0906-6713.2002.003421.x","article-title":"Periodontal diagnoses and classification of periodontal diseases","volume":"34","author":"Armitage","year":"2004","journal-title":"Periodontol. 2000"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1902\/jop.1967.38.6_part2.602","article-title":"The Periodontal Disease Index (PDI)","volume":"38","author":"Ramfjord","year":"1967","journal-title":"J. Periodontol."},{"key":"ref_34","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo","year":"1975","journal-title":"Int. Dent. J."},{"key":"ref_35","first-page":"138","article-title":"Evaluation of the Efficacy of Coenzyme Q10 in the Management of Chronic Periodontitis: A Clinical Study","volume":"9","author":"Pandav","year":"2021","journal-title":"Eur. J. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"014","DOI":"10.23937\/2469-5734\/1510014","article-title":"Doxycycline and Coenzyme Q10 Treatment Modalities for Chronic Periodontitis: A Preliminary Study","volume":"1","author":"Darweesh","year":"2015","journal-title":"Int. J. Oral Dent. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/2278-9626.141669","article-title":"A clinical and microbiological study to evaluate the effect of dietary supplement of coenzyme Q10 in nonsurgical treatment outcome of chronic periodontitis patients after phase 1 periodontal therapy","volume":"3","author":"Saini","year":"2014","journal-title":"Eur. J. Gen. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/0972-124X.99261","article-title":"Clinical evaluation of topical application of perio-Q gel (Coenzyme Q10) in chronic periodontitis patients","volume":"16","author":"Hans","year":"2012","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5005\/jp-journals-10029-1049","article-title":"Clinical and Microbiological Evaluation of Chlorine Dioxide Based Mouthwash and Toothpaste in Periodontitis Patients along with Combination of Nutritional Dietary Supplement of CoQ10","volume":"2","author":"Mani","year":"2013","journal-title":"Int. J. Exp. Dent. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_41","unstructured":"Cochrane Training (2022). Review Manager (RevMan), Cochrane Training."},{"key":"ref_42","first-page":"128","article-title":"Clinical and immunological evaluation of Coenzyme Q10 as an adjunct to nonsurgical periodontal therapy in chronic periodontitis patients","volume":"3","author":"Attia","year":"2016","journal-title":"J. Periodontal Med. Clin. Prac."},{"key":"ref_43","first-page":"475","article-title":"Natural antioxidant: Coenzyme Q10 (PERIO Q)TM in management of chronic periodontitis: A clinical study","volume":"1","author":"Chaudhry","year":"2014","journal-title":"Int. J. Dent. Health Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jobcr.2018.05.005","article-title":"Subgingivally delivered coenzyme Q10 in the treatment of chronic periodontitis among smokers: A randomized, controlled clinical study","volume":"9","author":"Raut","year":"2019","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.21608\/edj.2015.71409","article-title":"Coenzyme Q10 Food Supplement on the Treatment of Chronic Periodontitis in Patients with Type II Diabetes Mellitus: A Randomized Control Study","volume":"65","author":"Shoukheba","year":"2019","journal-title":"Egypt. Dent. J."},{"key":"ref_46","first-page":"80","article-title":"Comparative Evaluation of Locally Delivered Lycopene Gel and Coenzyme Q10 Gel as an Adjunct in the Treatment of Chronic Periodontitis: A Clinico-Biochemical Study","volume":"5","author":"Jha","year":"2018","journal-title":"Int. J. Prev. Clin. Dent. Res."},{"key":"ref_47","first-page":"69","article-title":"Clinical Evaluation of Co-enzyme Q10 in Management of Chronic Periodontitis Patients: Mouth Split Study","volume":"9","author":"Barakat","year":"2019","journal-title":"Int. J. Health Sci. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1055\/s-0040-1716596","article-title":"Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis","volume":"14","author":"Pranam","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4103\/0976-237X.188572","article-title":"Comparative evaluation of co-enzyme Q10 and Melaleuca alternifolia as antioxidant gels in treatment of chronic periodontitis: A clinical study","volume":"7","author":"Raut","year":"2016","journal-title":"Contemp. Clin. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0972-124X.138690","article-title":"A comparative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio Q\u2122) gel in chronic periodontitis patients: A clinical study","volume":"18","author":"Sale","year":"2014","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.12816\/0024721","article-title":"An Evaluation of the Effectiveness of Coenzyme Q10 Gel in Management of Patients with Chronic Periodontitis (II Inter Group Comparison)","volume":"28","author":"Salih","year":"2016","journal-title":"JBCD"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s13346-019-00698-z","article-title":"Innovative coenzyme Q10-loaded nanoformulation as an adjunct approach for the management of moderate periodontitis: Preparation, evaluation, and clinical study","volume":"10","author":"Shaheen","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/0972-124X.183097","article-title":"Comparative evaluation of coenzyme Q(10)-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis","volume":"20","author":"Sharma","year":"2016","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal Disease in Pregnancy I. Prevalence and Severity","volume":"21","author":"Loe","year":"1963","journal-title":"Acta Odontol. Scand."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal Disease in Pregnancy. II. Correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol. Scand."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1902\/jop.1984.55.11.629","article-title":"Histologic comparisons of interproximal gingival tissues related to the presence or absence of bleeding","volume":"55","author":"Abrams","year":"1984","journal-title":"J. Periodontol."},{"key":"ref_57","first-page":"117","article-title":"Role of professionally applied 0.8% hyaluronic acid gel in managing inflammation in periodontal disease","volume":"2","author":"Gupta","year":"2011","journal-title":"Baba Farid Univ. Dent. J."},{"key":"ref_58","first-page":"107","article-title":"Gingival sulcus bleeding\u2014a leading symptom in initial gingivitis","volume":"15","author":"Son","year":"1971","journal-title":"Helv. Odontol. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.1987.tb00298.x","article-title":"The microbiota associated with successful or failing osseointegrated titanium implants","volume":"2","author":"Mombelli","year":"1987","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_60","first-page":"905","article-title":"Motivation und Aufkl\u00e4rung","volume":"85","author":"Saxer","year":"1975","journal-title":"SSO. Schweiz. Mon. Zahnheilkd"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1902\/jop.1970.41.41.41","article-title":"Reduced plaque formation by the chloromethyl analogue of vitamine C","volume":"41","author":"Turesky","year":"1970","journal-title":"J. Periodontol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10787-021-00817-8","article-title":"Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: A systematic review and meta-analysis of randomized controlled- trials","volume":"29","author":"Alimohammadi","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10787-019-00572-x","article-title":"The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: A systematic review and meta-analysis of randomized controlled trials","volume":"27","author":"Jorat","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/jre.12984","article-title":"Does the use of omega-3 fatty acids as an adjunct to non-surgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta-analysis","volume":"57","author":"Furukawa","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"268","DOI":"10.18632\/oncotarget.13613","article-title":"Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?","volume":"8","author":"Qiu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/dju294","article-title":"Cigarette smoking and variations in systemic immune and inflammation markers","volume":"106","author":"Shiels","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"66","DOI":"10.24815\/jds.v5i2.20015","article-title":"Effect of coenzyme-q10 in the post-curettage against probing depth, relative attachment loss, and bleeding on probing","volume":"5","author":"Anwaristi","year":"2022","journal-title":"J. Syiah Kuala Dent. Soc."},{"key":"ref_72","unstructured":"Bhalla, A., Jithendra, K.D., and Shailendra, S. (2021, February 20). Co-Enzyme Q10:-Another Armour For Novel Periodontal Therapy. Available online: https:\/\/web.s.ebscohost.com\/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=09762248&AN=136410177&h=f4JoktM3lV6%2bOuVxrvdSxQFt4WhBLdCcL8PZu35rF3ZPWCKiIsMicGQW4iHybQSqx5IaE2p5X1Nh%2fcmTLAsZvA%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d09762248%26AN%3d136410177."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5005\/jp-journals-10024-2757","article-title":"Placement of Sticky Bone\u2122 in patients with generalized periodontitis previously treated with coenzyme Q10","volume":"21","author":"Chug","year":"2020","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_74","first-page":"333","article-title":"Bioenergetics in clinical medicine-X. Survey of the adjunctive use of coenzyme Q with oral therapy in treating periodontal disease","volume":"8","author":"Folkers","year":"1977","journal-title":"J. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"s241","DOI":"10.1016\/0098-2997(94)90034-5","article-title":"Effect of topical application of Coenzyme Q10 on adult periodontitis","volume":"15","author":"Hanioka","year":"1994","journal-title":"Mol. Asp. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.bdj.4808871","article-title":"Coenzyme Q10 and periodontal disease","volume":"179","author":"Lister","year":"1995","journal-title":"Br. Dent. J."},{"key":"ref_77","first-page":"ZC26-8","article-title":"Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health","volume":"9","author":"Manthena","year":"2015","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_78","first-page":"257","article-title":"Healing of periodontal tissue assisted by coenzyme Q10 with vitamin E\u2014Clinical and laboratory evaluation","volume":"59","author":"Stopa","year":"2007","journal-title":"Pharm. Rep."},{"key":"ref_79","first-page":"537","article-title":"Evidence for enhanced treatment of periodontal disease by therapy with coenzyme Q","volume":"43","author":"Matsumura","year":"1973","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_80","first-page":"84","article-title":"Deficiency of Coenzyme Q in Gingiva of Patients with Periodontal Disease","volume":"43","author":"Nakamura","year":"1973","journal-title":"J. Int. Vitaminol. Nutr."},{"key":"ref_81","first-page":"33","article-title":"Evaluation of efficacy of coenzyme Q 10 in management of gingivitis & slight periodontitis - a clinical study","volume":"4","author":"Pitale","year":"2012","journal-title":"Int. J. Curr. Pharm. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2334\/josnusd.18-0048","article-title":"Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment","volume":"61","author":"Rasperini","year":"2019","journal-title":"J. Oral Sci."},{"key":"ref_83","first-page":"13","article-title":"Clinical evaluation of topical application of CNBC gel (Coenzyme Q10) in chronic periodontitis patients","volume":"1","author":"Roopa","year":"2014","journal-title":"J. Dent. Res. Updates"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4103\/0975-7406.84471","article-title":"Coenzyme Q10: The essential nutrient","volume":"3","author":"Saini","year":"2011","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_85","first-page":"715","article-title":"Bioenergetics in clinical medicine. VI. Adjunctive treatment of periodontal disease with coenzyme Q10","volume":"14","author":"Wilkinson","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_86","first-page":"717","article-title":"Site-specific delivery of the Nutraceutical COQ10 for periodontal therapy","volume":"4","author":"Zaki","year":"2012","journal-title":"Int. J. Pharm. Pharm. 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