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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T07:52:27Z","timestamp":1705823547448},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1\/2015 to 11\/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage \u22652 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN.<\/jats:p>","DOI":"10.3390\/nu15051224","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T11:55:16Z","timestamp":1677585316000},"page":"1224","source":"Crossref","is-referenced-by-count":1,"title":["Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-0152-9830","authenticated-orcid":false,"given":"Walter","family":"Mihatsch","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ulm University, 89075 Ulm, Germany"},{"name":"Department of Health Management, Neu-Ulm University of Applied Sciences, 89231 Neu-Ulm, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8028-8635","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Jim\u00e9nez Varas","sequence":"additional","affiliation":[{"name":"Health Sciences Library, Hospital Universitario La Paz, 28046 Madrid, Spain"}]},{"given":"Lucia Lorenzino","family":"Diehl","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Department of Pediatrics, Hospital Universitario La Paz, Universidad Autonoma de Madrid, 28046 Madrid, Spain"}]},{"given":"Virgilio","family":"Carnielli","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Health, Division of Neonatology, G. Salesi Children\u2019s Hospital, 60123 Ancona, Italy"},{"name":"Department of Odontostomatologic and Specialized Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, Italy"}]},{"given":"Rahel","family":"Schuler","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Justus-Liebig-University, 35392 Giessen, Germany"}]},{"given":"Corinna","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Leipzig University Hospital, 04103 Leipzig, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-4793-1561","authenticated-orcid":false,"given":"Miguel","family":"S\u00e1enz de Pipa\u00f3n Marcos","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Department of Pediatrics, Hospital Universitario La Paz, Universidad Autonoma de Madrid, 28046 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.clnu.2018.05.029","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition","volume":"37","author":"Mihatsch","year":"2018","journal-title":"Clin. 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