uni-leipzig-open-access/json/jnnp-2022-329685

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Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>) and non-obese (BMI &lt;30 kg\/m<jats:sup>2<\/jats:sup>) patients and correlated with individual BMI values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p&lt;0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>\u2009and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>compared with patients with BMI &lt;30 kg\/m<jats:sup>2<\/jats:sup>after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p&lt;0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnnp-2022-329685","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:13Z","timestamp":1667347213000},"page":"57-61","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association of obesity with disease outcome in multiple 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