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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T06:43:56Z","timestamp":1706165036761},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ESC Heart Failure"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Chronic heart failure (HF) is a common disease and one of the leading causes of death worldwide. Heart failure with preserved ejection fraction (HFpEF) and with reduced ejection fraction (HFrEF) are different diseases with distinct as well as comparable pathophysiologies and diverse responses to therapeutic agents. We aimed to identify possible pathobiochemical signalling pathways and biomarkers in HFpEF and HFrEF by using a broad proteomic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 180 biomarkers in the plasma of a representative subgroup (71\u00a0years old) of HFpEF (70% female) with a left ventricular ejection fraction (LVEF)\u00a0\u2265\u00a050% and HFrEF (18% female) with an LVEF\u00a0\u2264\u00a040% patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0127) from the Prevalence and Clinical Course of Diastolic Dysfunction and Diastolic Heart Failure (DIAST\u2010CHF) trial were examined and compared with a healthy control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; 48% female). We were able to identify 35 proteins that were expressed significantly different in both HF groups compared with the control group. We determine 29 unique proteins expressed in HFpEF and 33 unique proteins in HFrEF. Significantly up\u2010regulated trefoil factor 3 (TFF3) and down\u2010regulated contactin\u20101 could be identified as previously unknown biomarkers for HF. However, TFF3 is also a predictive factor for the occurrence of a cardiovascular event in HFpEF patients. In HFpEF, serine protease 27 was found at reduced levels for the first time, which could offer a new therapeutic target. Additionally, network analyses showed a special role of platelet\u2010derived growth factor subunit A, Dickkopf\u2010related protein 1, and tumour necrosis factor receptor superfamily member 6 in HFpEF patients, whereas perlecan and junctional adhesion molecule A stood out in the HFrEF group. Overall, signalling pathways of metabolic processes, cellular stress, and iron metabolism seemed to be important for HFrEF, whereas for HFpEF, oxygen stress, haemostasis, cell renewal, cell migration, and cell proliferation are in the foreground.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The identified proteins and signalling pathways offer new therapeutic and diagnostic approaches for patients with chronic HF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ehf2.14167","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T03:50:27Z","timestamp":1664769027000},"page":"200-210","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biomarker profiles in heart failure with preserved vs. reduced ejection fraction: results from the DIAST\u2010CHF study"],"prefix":"10.1002","volume":"10","author":[{"given":"Abass","family":"Eidizadeh","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry\/Interdisciplinary UMG Laboratory University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}]},{"given":"Moritz","family":"Schnelle","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry\/Interdisciplinary UMG Laboratory University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site G\u00f6ttingen G\u00f6ttingen Germany"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}]},{"given":"Frank","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin Germany"},{"name":"Berlin Institute of Health Berlin Germany"}]},{"given":"Kathleen","family":"Nolte","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Pneumology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}]},{"given":"Stefanie Maria","family":"Werhahn","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Pneumology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}]},{"given":"Lutz","family":"Binder","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry\/Interdisciplinary UMG Laboratory University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site G\u00f6ttingen G\u00f6ttingen 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