uni-leipzig-open-access/json/apa.16766

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:05:15Z","timestamp":1703635515510},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the relationship between medical staff's response time (RT) to oxygen saturation (SpO<jats:sub>2<\/jats:sub>) below 80% and the associated time from tactile intervention until SpO<jats:sub>2<\/jats:sub> normalisation (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Time\u2010lapse video and continuous SpO<jats:sub>2<\/jats:sub> were recorded for six consecutive 24\u2009h periods. Regression analyses of RT and SpO<jats:sub>2<\/jats:sub> in association with postmenstrual age (PMA), weight, infant sex and frequency of intermittent hypoxemia (IH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and twelve hypoxemia episodes received tactile intervention in 20 extremely preterm infants (gestational age \u226428\u2009weeks, birthweight &lt;1500\u2009g). Median RT was 20.5\u2009s (IQR 16.63\u201325.50). RT increased with increased IH frequency (<jats:italic>p<\/jats:italic>\u2009=\u20090.023) independently of PMA and weight. SpO<jats:sub>2<\/jats:sub> decreased by 3.7% with every 10\u2009s RT (<jats:italic>p<\/jats:italic>\u2009=\u20090.039). Time until SpO<jats:sub>2<\/jats:sub> normalisation was strongly associated with RT (\u03b2\u2009=\u20090.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.042). The association was amplified by lower PMA (<jats:italic>p<\/jats:italic>\u2009=\u20090.043). Female preterm infants experienced longer RT than males (<jats:italic>p<\/jats:italic>\u2009=\u20090.027). Because the total length of an IH is the sum of RT and CT, preterm infants with low PMA can reach a critical hypoxemia duration of &gt;60\u2009s, even with short RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RT is a critical factor that affects the overall time of IH treatments and the depth of desaturation. The consequences of a prolonged RT are worse for more immature preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16766","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T15:33:45Z","timestamp":1679499225000},"page":"1413-1421","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of response time and intermittent hypoxemia in extremely preterm infants"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-6488-1714","authenticated-orcid":false,"given":"Sven","family":"Martin","sequence":"first","affiliation":[{"name":"Haptic Research Lab, Paul Flechsig Institute of Brain Research University of Leipzig  Leipzig Germany"}]},{"given":"Benjamin W.","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Division of Neonatology University Hospital for Children and Adolescents  Leipzig Germany"}]},{"given":"Ulrich H.","family":"Thome","sequence":"additional","affiliation":[{"name":"Division of Neonatology University Hospital for Children and Adolescents  Leipzig Germany"}]},{"given":"Martin","family":"Grunwald","sequence":"additional","affiliation":[{"name":"Haptic Research Lab, Paul Flechsig Institute of Brain Research University of Leipzig  Leipzig Germany"}]},{"given":"Stephanie M.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Haptic Research Lab, Paul Flechsig Institute of Brain Research University of Leipzig  Leipzig 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