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However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high\u2010aged, population\u2010based cohort (<jats:italic>N<\/jats:italic> = 3217) and validated using Cox\u2010regression of dementia\u2010conversion. In 334 cognitively unimpaired SCD\u2010patients from memory\u2010clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the population\u2010based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD\u2010patients from memory\u2010clinics, high DS were associated with greater cognitive decline. CSF A\u00df42 predicted increasing DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>SCD typically precedes DS in the evolution to dementia. SCD\u2010patients from memory\u2010clinics with DS may constitute a high\u2010risk group for cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Emerging or persistent DS after SCD reports predict dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In SCD patients, more amyloid pathology relates to increasing DS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SCD patients with DS are at high risk for symptomatic 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