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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T16:42:48Z","timestamp":1701880968074},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n Background Non-alcoholic fatty liver disease (NAFLD) affects more\n than 18 million individuals in Germany. Real-world data help to better characterize the\n natural history of disease and standard of care.<\/jats:p><jats:p>\n Methods The German NAFLD-Registry is a prospective\n non-interventional study initiated by the German Liver Foundation and aims to describe\n clinical characteristics and observe outcomes in patients with NAFLD recruited in secondary\n and tertiary care.<\/jats:p><jats:p>\n Results From this ongoing study, baseline data of the first 501\n patients (mean age 54 years, 48% women) were analysed. 13 % of the study population had a high\n risk for advanced fibrosis (FIB-4 \u22652.67), approximately one-third had a liver stiffness value\n \u22659.6kPa measured by transient elastography, and the clinical diagnosis of liver cirrhosis was\n present in 10%. Typical comorbidities were more prevalent in high risk as compared to low risk\n patients (FIB-4 <1.3) including arterial hypertension (85 vs. 42%), hypercholesterolemia\n (39 vs. 16%), and type 2 diabetes mellitus (T2DM) (69 vs. 26%). Patients with T2DM (192\/501)\n had a higher NAFLD disease burden as shown by liver stiffness values \u22659.6 kPa (51%) and\n clinical diagnosis of cirrhosis (20%). Statins were used in 22% of the main population, while\n in diabetic patients, metformin, GLP-1 agonists, and SGLT2 inhibitors were used in 65, 17, and\n 17%, respectively. Uptake of life-style interventions such as physical exercise or nutritional\n counselling was generally low.<\/jats:p><jats:p>\n Conclusion First data of the German NAFLD registry show that\n approximately every 10th patient has advanced NAFLD, highlights T2DM patients as a high-risk\n group and gives insights in the use of comedication and life-style interventions in secondary\n and tertiary care.<\/jats:p>","DOI":"10.1055\/a-1986-7676","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T23:57:16Z","timestamp":1673308636000},"page":"60-70","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics of patients with non-alcoholic fatty liver disease (NAFLD) in Germany \u2013 First data from the German NAFLD-Registry"],"prefix":"10.1055","volume":"61","author":[{"given":"Andreas","family":"Geier","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}]},{"given":"Monika","family":"Rau","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}]},{"given":"Anita","family":"Pathil-Warth","sequence":"additional","affiliation":[{"name":"Goethe University Hospital, Frankfurt am Main, Germany"}]},{"given":"Manfred","family":"von der Ohe","sequence":"additional","affiliation":[{"name":"Gastroenterologische Studiengesellschaft Herne, Herne, Germany"}]},{"given":"J\u00f6rn","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}]},{"given":"Nektarios","family":"Dikopoulos","sequence":"additional","affiliation":[{"name":"Praxis Ludwig & Dikopoulos, Dornstadt, Germany"},{"name":"Klinik f\u00fcr Innere Medizin 1, Ulm University Medical Center, Ulm, Germany"}]},{"given":"Kerstin","family":"Stein","sequence":"additional","affiliation":[{"name":"Hepatologie Magdeburg, Magdeburg, Germany"}]},{"given":"Yvonne","family":"Serfert","sequence":"additional","affiliation":[{"name":"Leberstiftungs-GmbH Deutschland, Hannover, Germany"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"University Hospital Leipzig, Leipzig, Germany"}]},{"given":"Peter","family":"Buggisch","sequence":"additional","affiliation":[{"name":"ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany"}]},{"given":"M\u00fcnevver","family":"Demir","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Medicine, Campus Virchow Clinic, Berlin, Germany"}]},{"given":"Elke","family":"Roeb","sequence":"additional","affiliation":[{"name":"Justus Liebig-University Giessen and University Hospital, Giessen, Germany"}]},{"given":"Bianka","family":"Wiebner","sequence":"additional","affiliation":[{"name":"Deutsche Leberstiftung, Hannover, Germany"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Hannover, Germany"},{"name":"Leberstiftungs-GmbH Deutschland, Hannover, Germany"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Goethe University Hospital, Frankfurt am Main, Germany"}]},{"given":"Wolf P.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Gastroenterologie am Bayerischen Platz, Berlin, Germany"}]}],"member":"194","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and\n prevention","volume":"15","author":"Z Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic\n Steatohepatitis","volume":"69","author":"Z 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Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1986-7676.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T07:58:05Z","timestamp":1676447885000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1986-7676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":30,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,9]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"http:\/\/dx.doi.org\/10.1055\/a-1986-7676","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"value":"0044-2771","type":"print"},{"value":"1439-7803","type":"electronic"}],"subject":["Gastroenterology"],"published":{"date-parts":[[2023,1]]}}} |