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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:17:35Z","timestamp":1706055455985},"reference-count":76,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher"},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EFRE-0200481"]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxindoles and iso\u2010oxindoles are natural product\u2010derived scaffolds that provide inspiration for the design and synthesis of novel biologically relevant compound classes. Notably, the spirocyclic connection of oxindoles with <jats:italic>iso<\/jats:italic>\u2010oxindoles has not been explored by nature but promises to provide structurally related compounds endowed with novel bioactivity. Therefore, methods for their efficient synthesis and the conclusive discovery of their cellular targets are highly desirable. We describe a selective Rh<jats:sup>III<\/jats:sup>\u2010catalyzed scaffold\u2010divergent synthesis of spirooxindole\u2013isooxindoles and spirooxindole\u2013oxindoles from differently protected diazooxindoles and <jats:italic>N<\/jats:italic>\u2010pivaloyloxy aryl amides which includes a functional group\u2010controlled Lossen rearrangement as key step. Unbiased morphological profiling of a corresponding compound collection in the Cell Painting assay efficiently identified the mitotic kinesin Eg5 as the cellular target of the spirooxindoles, defining a unique Eg5 inhibitor chemotype.<\/jats:p>","DOI":"10.1002\/anie.202301955","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T18:14:06Z","timestamp":1678990446000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles"],"prefix":"10.1002","volume":"62","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Shubhadip","family":"Mallick","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Yusheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Corentin","family":"Grassin","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum Faculty of Chemistry and Biochemistry Organic Chemistry II University-Street 150 44801 Bochum Germany"}]},{"given":"Bel\u00e9n","family":"Lucas","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Beate","family":"Sch\u00f6lermann","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Axel","family":"Pahl","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Street 11 44227 Dortmund Germany"},{"name":"Compound Management and Screening Center Otto-Hahn-Street 11 44227 Dortmund Germany"}]},{"given":"Rebecca","family":"Scheel","sequence":"additional","affiliation":[{"name":"T
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