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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T04:48:29Z","timestamp":1681361309416},"reference-count":65,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klinische Neurophysiologie"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bei der Amyotrophen Lateralsklerose (ALS) handelt sich um eine neurodegenerative\n Multisystemerkrankung. Diese \u00e4u\u00dfert sich neben den motorischen\n Defiziten mit nicht-motorischen Symptomen. Hierzu z\u00e4hlen auch autonome\n St\u00f6rungen, die von ver\u00e4nderter Schwei\u00dfsekretion\n \u00fcber Tachykardie bis zu gastrointestinalen Symptomen reichen. Autonome\n St\u00f6rungen k\u00f6nnen mit verschiedenen Methoden, wie\n Selbsterhebungsfrageb\u00f6gen, Messung der Herzfrequenzvariabilit\u00e4t,\n QTc-Intervallmessung, Erhebung der sudomotorischen Funktion und Sonographie des\n Nervus vagus erfasst werden, die in diesem Artikel dargestellt werden. Die\n bislang bei der ALS eingesetzten Methoden der autonomen Diagnostik ergeben zum\n Teil deutlich divergierende Ergebnisse \u00fcber die Aktivit\u00e4t des\n Sympathikus im Krankheitsverlauf. Relevante autonome St\u00f6rungen scheinen\n zumeist erst im fortgeschrittenen Krankheitsstadium aufzutreten, wobei\n multizentrische Studien mit longitudinalem Ansatz ausstehen.<\/jats:p>","DOI":"10.1055\/a-2018-3174","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T23:39:25Z","timestamp":1678837165000},"page":"22-27","source":"Crossref","is-referenced-by-count":0,"title":["Autonome Diagnostik bei der Amyotrophen\n Lateralsklerose"],"prefix":"10.1055","volume":"54","author":[{"given":"Moritz","family":"Metelmann","sequence":"additional","affiliation":[{"name":"Department of Neurology,Universit\u00e4tsklinikum Leipzig, Leipzig,\n Germany"}]},{"given":"Petra","family":"Baum","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie , Universit\u00e4tsklinikum Leipzig,\n Leipzig, Germany"}]},{"given":"Johann","family":"Pelz","sequence":"additional","affiliation":[{"name":"Department of Neurology,Universit\u00e4tsklinikum Leipzig, Leipzig,\n Germany"}]}],"member":"194","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fneur.2016.00117","article-title":"Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases","volume":"7","author":"R G\u00fcnther","year":"2016","journal-title":"Front Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/01.wco.0000183114.76056.0e","article-title":"Autonomic impairment in amyotrophic lateral sclerosis","volume":"18","author":"R Baltadzhieva","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.17925\/ENR.2013.08.01.46","article-title":"Sympathetic Hyperactivity and Sympathovagal Imbalance in Amyotrophic Lateral\n Sclerosis","volume":"8","author":"T. Shimizu","year":"2012","journal-title":"European Neurological Review"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0022-510x(94)90009-4","article-title":"Circulatory collapse and sudden death in respirator-dependent amyotrophic\n lateral sclerosis","volume":"124","author":"T Shimizu","year":"1994","journal-title":"Journal of the Neurological Sciences"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s00415-021-10651-1","article-title":"A systematic review of non-motor
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