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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:05:35Z","timestamp":1697691935762},"reference-count":36,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Low skeletal muscle mass (LSMM) can be assessed by cross-sectional imaging. LSMM is associated with several clinically relevant factors in various disorders with predictive and prognostic implications. Methods: Our aim was to establish the effect of computed tomography (CT)-defined LSMM on mortality in renal cell cancer (RCC) and urothelial carcinoma (UC) undergoing palliative treatment. The MEDLINE library, Cochrane, and SCOPUS databases were screened for the associations between CT-defined LSMM up to May 2022. In total, 11 studies were suitable for the analysis. Results: The included studies comprised 481 patients with RCC and 394 patients with UC. The pooled hazard ratio for the association between LSMM and overall survival was 1.64 (95% CI: 0.90\u20132.99), p = 0.10 in univariable analysis and 1.55 (95% CI: 0.91\u20132.63), p = 0.10 in multivariable analysis for RCC. For UC, the pooled hazard ratio was 2.75 (95% CI: 1.77\u20134.28), p < 0.00001 in univariable, and 2.77 (95% CI: 1.91\u20134.02), p < 0.00001 in multivariable analysis. For progression-free survival, it was 2.02 (95% CI: 1.24\u20133.27), p = 0.004 for RCC and 2.43 (95% CI: 1.59\u20133.74), p < 0.0001 for UC (univariable analysis). Conclusions: CT-defined LSMM predicts OS and PFS in RCC and UC in the palliative setting. The effect was higher in UC. Therefore, LSMM assessment should be included as a relevant prognostic biomarker in clinical routine. <\/jats:p>","DOI":"10.1159\/000527277","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T01:41:15Z","timestamp":1669945275000},"page":"219-229","source":"Crossref","is-referenced-by-count":0,"title":["Low Skeletal Muscle Mass Predicts Relevant Outcomes in Palliative Urological Oncology: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"107","author":[{"given":"Hans-Jonas","family":"Meyer","sequence":"first","affiliation":[]},{"given":"Andreas","family":"Wienke","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Zamsheva","sequence":"additional","affiliation":[]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(08)70153-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.15.14635"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06573-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.04.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3428"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60229-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.7036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010143"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.2016.45"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.11.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal
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