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The angiogenic factors soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF) are altered in pregnancies complicated by placenta\u2010related disorders. In this Review, we summarize the existing knowledge, examining the performance of maternal PlGF, sFlt\u20101 and the sFlt\u20101\/PlGF ratio for screening PE, predicting development of PE in the short term, diagnosing PE, monitoring established PE and predicting other placenta\u2010related disorders in singleton pregnancy. We also discuss the performance of PlGF and the sFlt\u20101\/PlGF ratio for predicting PE in twin pregnancy. For first\u2010trimester screening in singleton pregnancy, a more accurate way of identifying high\u2010risk women than current practice is to combine maternal PlGF levels with clinical risk factors and ultrasound markers. Later in pregnancy, the sFlt\u20101\/PlGF ratio has advantages over PlGF because it has a higher pooled sensitivity and specificity for diagnosing and monitoring PE. It has clinical value because it can rule out the development of PE in the 1\u20134\u2010week period after the test. Once a diagnosis of PE is established, repeat measurement of sFlt\u20101 and PlGF can help monitor progression of the condition and may inform clinical decision\u2010making regarding the optimal time for delivery. The sFlt\u20101\/PlGF ratio is useful for predicting FGR and preterm delivery, but the association between stillbirth and the angiogenic factors is unclear. The sFlt\u20101\/PlGF ratio can be used to predict PE in twin pregnancy, although different sFlt\u20101\/PlGF ratio cut\u2010offs from those for singleton pregnancy should be applied for optimal performance. In summary, PlGF, sFlt\u20101 and the sFlt\u20101\/PlGF ratio are useful for screening, diagnosing, predicting and monitoring placenta\u2010related disorders in singleton and twin pregnancy. We propose that tests for these angiogenic factors are integrated more fully into clinical practice.\u00a9 2022 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>","DOI":"10.1002\/uog.26032","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T16:59:52Z","timestamp":1657558792000},"page":"168-180","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical utility of <scp>sFlt<\/scp>\u20101 and <scp>PlGF<\/scp> in screening, prediction, diagnosis and monitoring of pre\u2010eclampsia and fetal growth restriction"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-1264-7365","authenticated-orcid":false,"given":"H.","family":"Stepan","sequence":"first","affiliation":[{"name":"University Hospital Leipzig  Leipzig Germany"}]},{"given":"A.","family":"Galindo","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre  Madrid Spain"}]},{"given":"M.","family":"Hund","sequence":"additional","affiliation":[{"name":"Roche Diagnostics International Ltd  Rotkreuz Switzerland"}]},{"given":"D.","family":"Schlembach","sequence":"additional","affiliation":[{"name":"Clinicum Vivantes Neukoelln  Berlin Germany"}]},{"given":"J.","family":"Sillman","sequence":"additional","affiliation":[{"name":"Roche Diagnostics International Ltd  Rotkreuz Switzerland"}]},{"given":"D.","family":"Surbek","sequence":"additional","affiliation":[{"name":"University Hospital, University of Bern  Bern Switzerland"}]},{"given":"M.","family":"Vatish","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's &amp; 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