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Although an infection of the placenta may be rare, pregnancy may occasionally be affected by intrauterine failure. The knowledge of placental morphology on sudden intrauterine demise is still limited.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fetal and placental tissue of two cases of sudden intrauterine death in the second trimester were analysed morphologically and by immunohistochemistry. One case was evaluated by RT-PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both mothers were tested positive for the Alpha variant of SARS-CoV-2 but were oligosymptomatic for COVID-19. Unexpected sudden intrauterine death (SIUD) occurred at 15\u2009+\u20092 and 27\u2009+\u20093\u00a0weeks of gestation. One fetus demonstrated an intrauterine growth restriction. No malformations nor inflammatory changes were observed in either fetus on autopsy. In contrast to the placentas, the fetal tissue was negative for SARS-CoV-2 on immunohistochemical and RT-PCR analyses. Macroscopically, the placentas showed an increased consistency with a white, reticular cutting surface covering about 95% of the whole placenta. Only very focal histiocytic chronic intervillositis was noted histologically. Massive perivillous fibrin deposits with extensive necroses of the villous trophoblast were present in more than 90% of the placental tissue. Immunohistochemical staining was strong and diffusely positive for SARS-CoV-2 in the villous trophoblast and rarely within the villous stromal cells. Placental SARS-CoV-2 infection was confirmed by RT-PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Sudden intrauterine death may occur in mothers who are oligosymptomatic for COVID-19. Acute placental failure is responsible for SIUD, demonstrated by massive perivillous fibrin deposits and extensive necroses of the villous trophoblast with SARS-CoV-2-positivity based on immunohistochemical staining and RT-PCR. Detailed histopathological examination of placental and fetal tissue is mandatory to verify SARS-CoV-2 and to evaluate the pathogenesis and functionality of this disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06614-0","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T05:02:43Z","timestamp":1655528563000},"page":"1811-1822","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Placental pathology in sudden intrauterine death (SIUD) in SARS-CoV-2-positive oligosymptomatic women"],"prefix":"10.1007","volume":"307","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-9775-4858","authenticated-orcid":false,"given":"Lars-Christian","family":"Horn","sequence":"first","affiliation":[]},{"given":"Irene","family":"Kr\u00fccken","sequence":"additional","affiliation":[]},{"given":"Grit Gesine Ruth","family":"Hiller","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Niedermair","sequence":"additional","affiliation":[]},{"given":"Kristina","family":"Perac","sequence":"additional","affiliation":[]},{"given":"Corinna","family":"Pietsch","sequence":"additional","affiliation":[]},{"given":"Anne Kathrin","family":"H\u00f6hn","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"6614_CR1","doi-asserted-by":"publisher","first-page":"205031212110029","DOI":"10.1177\/20503121211002996","volume":"9","author":"W Alam","year":"2021","unstructured":"Alam W (2021) Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders. 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