{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:11:20Z","timestamp":1696857080500},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"crossref"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Cystic fibrosis (CF) is one of the most common inherited and life-shortening pulmonary diseases in the Caucasian population. With the widespread introduction of newborn screening and the development of modulator therapy, tremendous advances have been made in recent years both in diagnosis and therapy. Since paediatric CF patients tend to be younger and have lower morbidity, the type of imaging modality that should be used to monitor the disease is often debated. Computed tomography (CT) is sensitive to many pulmonary pathologies, but radiation exposure limits its use, especially in children and adolescents. Conventional pulmonary magnetic\u00a0resonance imaging (MRI) is a valid alternative to CT and, in most cases, provides sufficient information to guide treatment. Given the expected widespread availability of sequences with ultra-short echo times, there will be even fewer reasons to perform CT for follow-up of patients with CF. This review aims to provide an overview of the process and results of monitoring CF with MRI, particularly for centres not specialising in the disease.<\/jats:p>","DOI":"10.1007\/s00247-022-05539-9","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T01:03:08Z","timestamp":1668387788000},"page":"640-648","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chest magnetic resonance imaging in cystic fibrosis: technique and clinical benefits"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-7680-0990","authenticated-orcid":false,"given":"Daniel","family":"Gr\u00e4fe","sequence":"first","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-2838-593X","authenticated-orcid":false,"given":"Freerk","family":"Prenzel","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0960-3740","authenticated-orcid":false,"given":"Franz Wolfgang","family":"Hirsch","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"5539_CR1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3390\/genes11060589","volume":"11","author":"V Scotet","year":"2020","unstructured":"Scotet V, L\u2019Hostis C, F\u00e9rec C (2020) The changing epidemiology of cystic fibrosis: Incidence, survival and impact of the CFTRGene discovery. Genes (Basel) 11:589","journal-title":"Genes (Basel)"},{"key":"5539_CR2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.jcf.2008.03.007","volume":"7","author":"PM Farrell","year":"2008","unstructured":"Farrell PM (2008) The prevalence of cystic fibrosis in the European Union. J Cyst Fibros 7:450\u2013453","journal-title":"J Cyst Fibros"},{"key":"5539_CR3","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","volume":"388","author":"JS Elborn","year":"2016","unstructured":"Elborn JS (2016) Cystic fibrosis. Lancet 388:2519\u20132531","journal-title":"Lancet"},{"key":"5539_CR4","first-page":"3","volume":"42","author":"IM Balfour-Lynn","year":"2020","unstructured":"Balfour-Lynn IM, King JA (2020) CFTR modulator therapies \u2013 Effect on life expectancy in people with cystic fibrosis. Paediatr Respir Rev 42:3\u20138","journal-title":"Paediatr Respir Rev"},{"key":"5539_CR5","first-page":"CD001402","volume":"2009","author":"KW Southern","year":"2009","unstructured":"Southern KW, M\u00e9relle MM, Dankert-Roelse JE, Nagelkerke AD (2009) Newborn screening for cystic fibrosis. Cochrane Database Syst Rev 2009:CD001402","journal-title":"Cochrane Database Syst Rev"},{"key":"5539_CR6","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1056\/NEJMoa1105185","volume":"365","author":"BW Ramsey","year":"2011","unstructured":"Ramsey BW, Davies J, McElvaney NG et al (2011) A CFTR potentiator in patients with\u00a0cystic fibrosis and the G551D mutation. N Engl J Med 365:1663\u20131672","journal-title":"N Engl J Med"},{"key":"5539_CR7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1183\/09031936.03.00006603","volume":"23","author":"PA de Jong","year":"2004","unstructured":"de Jong PA, Nakano Y, Lequin MH et al (2004) Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis. Eur Respir J 23:93\u201397","journal-title":"Eur Respir J"},{"key":"5539_CR8","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1164\/rccm.202102-0278OC","volume":"204","author":"M Stahl","year":"2021","unstructured":"Stahl M, Steinke E, Graeber SY et al (2021) Magnetic resonance imaging detects progression of lung disease and impact of newborn screening in preschool children with cystic fibrosis. Am J Respir Crit Care Med 204:943\u2013953","journal-title":"Am J Respir Crit Care Med"},{"key":"5539_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.prrv.2006.04.002","volume":"7","author":"HAWM Tiddens","year":"2006","unstructured":"Tiddens HAWM (2006) Chest computed tomography scans should be considered as a routine investigation in cystic fibrosis. Paediatr Respir Rev 7:202\u2013208","journal-title":"Paediatr Respir Rev"},{"key":"5539_CR10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1164\/rccm.201604-0893OC","volume":"195","author":"M Stahl","year":"2016","unstructured":"Stahl M, Wielp\u00fctz MO, Graeber SY et al (2016) Comparison of lung clearance index and magnetic resonance imaging for assessment of lung disease in children with cystic fibrosis. Am J Respir Crit Care Med 195:349\u2013359","journal-title":"Am J Respir Crit Care Med"},{"key":"5539_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1148\/radiol.2017162350","volume":"285","author":"G Dournes","year":"2017","unstructured":"Dournes G, Berger P, Refait J et al (2017) Allergic bronchopulmonary aspergillosis in cystic fibrosis: MR imaging of airway mucus contrasts as a tool for diagnosis. Radiology 285:261\u2013269","journal-title":"Radiology"},{"key":"5539_CR12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s00330-017-4870-4","volume":"28","author":"JF Schaefer","year":"2018","unstructured":"Schaefer JF, Hector A, Schmidt K et al (2018) A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results. Eur Radiol 28:74\u201384","journal-title":"Eur Radiol"},{"key":"5539_CR13","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.ejrad.2011.02.045","volume":"81","author":"M Eichinger","year":"2012","unstructured":"Eichinger M, Optazaite DE, Kopp-Schneider A et al (2012) Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur J Radiol 81:1321\u20131329","journal-title":"Eur J Radiol"},{"key":"5539_CR14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/ppul.23328","volume":"51","author":"LA Tepper","year":"2016","unstructured":"Tepper LA, Ciet P, Caudri D et al (2016) Validating chest MRI to detect and monitor cystic fibrosis lung disease in a pediatric cohort. Pediatr Pulmonol 51:34\u201341","journal-title":"Pediatr Pulmonol"},{"key":"5539_CR15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1148\/radiology.213.2.r99nv04537","volume":"213","author":"TH Helbich","year":"1999","unstructured":"Helbich TH, Heinz-Peer G, Eichler I et al (1999) Cystic fibrosis: CT assessment of lung involvement in children and adults. Radiology 213:537\u2013544","journal-title":"Radiology"},{"key":"5539_CR16","doi-asserted-by":"publisher","first-page":"e0244638","DOI":"10.1371\/journal.pone.0244638","volume":"15","author":"J Glandorf","year":"2020","unstructured":"Glandorf J, Klime\u0161 F, Voskrebenzev A et al (2020) Comparison of phase-resolved functional lung (PREFUL) MRI derived perfusion and ventilation parameters at 1.5T and 3T in healthy volunteers. PLoS One 15:e0244638","journal-title":"PLoS One"},{"key":"5539_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1148\/radiol.2462070712","volume":"246","author":"DM Hansell","year":"2008","unstructured":"Hansell DM, Bankier AA, MacMahon H et al (2008) Fleischner Society: Glossary of terms for thoracic imaging. Radiology 246:697\u2013722","journal-title":"Radiology"},{"key":"5539_CR18","first-page":"371","volume":"114","author":"H Ittrich","year":"2017","unstructured":"Ittrich H, Bockhorn M, Klose H, Simon M (2017) The diagnosis and treatment of hemoptysis. Dtsch Arztebl Int 114:371\u2013381","journal-title":"Dtsch Arztebl Int"},{"key":"5539_CR19","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/ppul.10280","volume":"35","author":"S Terheggen-Lagro","year":"2003","unstructured":"Terheggen-Lagro S, Truijens N, Van Poppel N et al (2003) Correlation of six different cystic fibrosis chest radiograph scoring systems with clinical parameters. Pediatr Pulmonol 35:441\u2013445","journal-title":"Pediatr Pulmonol"},{"key":"5539_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/BF01314939","volume":"2","author":"AR Chrispin","year":"1974","unstructured":"Chrispin AR, Norman AP (1974) The systematic evaluation of the chest radiograph in cystic fibrosis. Pediatr Radiol 2:101\u2013105","journal-title":"Pediatr Radiol"},{"key":"5539_CR21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1164\/rccm.200603-343OC","volume":"175","author":"SD Davis","year":"2007","unstructured":"Davis SD, Fordham LA, Brody AS et al (2007) Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med 175:943\u2013950","journal-title":"Am J Respir Crit Care Med"},{"key":"5539_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jcf.2019.04.016","volume":"19","author":"EJ Zucker","year":"2020","unstructured":"Zucker EJ, Barnes ZA, Lungren MP et al (2020) Deep learning to automate Brasfield chest radiographic scoring for cystic fibrosis. J Cyst Fibros 19:131\u2013138","journal-title":"J Cyst Fibros"},{"issue":"Suppl 1","key":"5539_CR23","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/j.jcf.2014.03.010","volume":"13","author":"AR Smyth","year":"2014","unstructured":"Smyth AR, Bell SC, Bojcin S et al (2014) European Cystic Fibrosis Society Standards of Care: Best Practice guidelines. J Cyst Fibros 13(Suppl 1):S23\u2013S42","journal-title":"J Cyst Fibros"},{"key":"5539_CR24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00247-018-4295-5","volume":"49","author":"A Kino","year":"2019","unstructured":"Kino A, Zucker EJ, Honkanen A et al (2019) Ultrafast pediatric chest computed tomography: comparison of free-breathing vs. breath-hold imaging with and without anesthesia in young children. Pediatr Radiol 49:301\u2013307","journal-title":"Pediatr Radiol"},{"key":"5539_CR25","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s00247-020-04706-0","volume":"51","author":"S Joyce","year":"2021","unstructured":"Joyce S, Carey BW, Moore N et al (2021) Computed tomography in cystic fibrosis lung disease: a focus on radiation exposure. Pediatr Radiol 51:544\u2013553","journal-title":"Pediatr Radiol"},{"key":"5539_CR26","doi-asserted-by":"publisher","first-page":"393.e9","DOI":"10.1016\/j.crad.2020.12.003","volume":"76","author":"F Moloney","year":"2021","unstructured":"Moloney F, Kavanagh RG, Ronan NJ et al (2021) Ultra-low-dose thoracic CT with model-based iterative reconstruction (MBIR) in cystic fibrosis patients undergoing treatment with cystic fibrosis transmembrane conductance regulators (CFTR). Clin Radiol 76:393.e9-393.e17","journal-title":"Clin Radiol"},{"key":"5539_CR27","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1001\/jamapediatrics.2013.311","volume":"167","author":"DL Miglioretti","year":"2013","unstructured":"Miglioretti DL, Johnson E, Williams A et al (2013) The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr 167:700\u2013707","journal-title":"JAMA Pediatr"},{"key":"5539_CR28","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1007\/s00247-019-04594-z","volume":"50","author":"FW Hirsch","year":"2020","unstructured":"Hirsch FW, Sorge I, Vogel-Claussen J et al (2020) The current status and further prospects for lung magnetic resonance imaging in pediatric radiology. Pediatr Radiol 50:734\u2013749","journal-title":"Pediatr Radiol"},{"key":"5539_CR29","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1097\/RLI.0000000000000178","volume":"50","author":"DM Renz","year":"2015","unstructured":"Renz DM, Scholz O, B\u00f6ttcher J et al (2015) Comparison between magnetic resonance imaging and computed tomography of the lung in patients with cystic fibrosis with regard to clinical, laboratory, and pulmonary functional parameters. Investig Radiol 50:733\u2013742","journal-title":"Investig Radiol"},{"key":"5539_CR30","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1148\/radiol.2020201138","volume":"297","author":"H Hatabu","year":"2020","unstructured":"Hatabu H, Ohno Y, Gefter WB et al (2020) Expanding applications of pulmonary MRI in the clinical evaluation of lung disorders: Fleischner Society Position Paper. Radiology 297:286\u2013301","journal-title":"Radiology"},{"key":"5539_CR31","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1016\/j.chest.2020.12.008","volume":"159","author":"G Dournes","year":"2021","unstructured":"Dournes G, Walkup LL, Benlala I et al (2021) The clinical use of lung MRI in cystic fibrosis. Chest 159:2205\u20132217","journal-title":"Chest"},{"key":"5539_CR32","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/jmri.27030","volume":"52","author":"JC Woods","year":"2020","unstructured":"Woods JC, Wild JM, Wielp\u00fctz MO et al (2020) Current state of the art MRI for the longitudinal assessment of cystic fibrosis. J Magn Reson Imaging 52:1306\u20131320","journal-title":"J Magn Reson Imaging"},{"key":"5539_CR33","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s13244-011-0146-8","volume":"3","author":"J Biederer","year":"2012","unstructured":"Biederer J, Beer M, Hirsch W et al (2012) MRI of the lung (2\/3). Why... when \u2026 how? Insights Imaging 3:355\u2013371","journal-title":"Insights Imaging"},{"key":"5539_CR34","doi-asserted-by":"publisher","first-page":"e200611","DOI":"10.1148\/ryct.2021200611","volume":"3","author":"AE Campbell-Washburn","year":"2021","unstructured":"Campbell-Washburn AE, Malayeri AA, Jones EC et al (2021) T2-weighted lung imaging using a 0.55-T MRI system. Radiol Cardiothorac Imaging 3:e200611","journal-title":"Radiol Cardiothorac Imaging"},{"key":"5539_CR35","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mri.2019.04.015","volume":"61","author":"G Chassagnon","year":"2019","unstructured":"Chassagnon G, Martin C, Ben Hassen W et al (2019) High-resolution lung MRI with ultrashort-TE: 1.5 or 3 Tesla? Magn Reson Imaging 61:97\u2013103","journal-title":"Magn Reson Imaging"},{"key":"5539_CR36","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1007\/s00330-016-4218-5","volume":"26","author":"G Dournes","year":"2016","unstructured":"Dournes G, Menut F, Macey J et al (2016) Lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution. Eur Radiol 26:3811\u20133820","journal-title":"Eur Radiol"},{"key":"5539_CR37","first-page":"344","volume":"18","author":"M Wielp\u00fctz","year":"2012","unstructured":"Wielp\u00fctz M, Kauczor H-U (2012) MRI of the lung: state of the art. Diagn Interv Radiol 18:344\u2013353","journal-title":"Diagn Interv Radiol"},{"key":"5539_CR38","first-page":"415","volume":"191","author":"MO Wielp\u00fctz","year":"2019","unstructured":"Wielp\u00fctz MO, Triphan SMF, Ohno Y et al (2019) Outracing lung signal decay \u2013 potential of ultrashort echo time MRI. R\u00f6Fo 191:415\u2013423","journal-title":"R\u00f6Fo"},{"key":"5539_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156272","volume":"11","author":"A Cieszanowski","year":"2016","unstructured":"Cieszanowski A, Lisowska A, Dabrowska M et al (2016) MR imaging of pulmonary nodules: detection rate and accuracy of size estimation in comparison to computed tomography. PLoS ONE 11:e0156272","journal-title":"PLoS ONE"},{"key":"5539_CR40","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ejrad.2008.05.017","volume":"68","author":"W Hirsch","year":"2008","unstructured":"Hirsch W, Sorge I, Krohmer S et al (2008) MRI of the lungs in children. Eur J Radiol 68:278\u2013288","journal-title":"Eur J Radiol"},{"key":"5539_CR41","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/jmri.21485","volume":"28","author":"S Morita","year":"2008","unstructured":"Morita S, Ueno E, Suzuki K, Machida H, Fujimura M, Kojima S, Hirata M, Ohnishi T, Imura C (2008) Navigator-triggered prospective acquisition correction (PACE) technique vs. conventional respiratory-triggered technique for free-breathing 3D MRCP: an initial prospective comparative study using healthy volunteers. J Magn Reson Imaging 28:673\u2013677","journal-title":"J Magn Reson Imaging"},{"key":"5539_CR42","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/mrm.22687","volume":"65","author":"C Santelli","year":"2011","unstructured":"Santelli C, Nezafat R, Goddu B, Manning WJ, Smink J, Kozerke S, Peters DC (2011) Respiratory bellows revisited for motion compensation: preliminary experience for cardiovascular MR. Magn Reson Med 65:1097\u20131102","journal-title":"Magn Reson Med"},{"key":"5539_CR43","doi-asserted-by":"publisher","first-page":"3830","DOI":"10.1007\/s00330-016-4248-z","volume":"26","author":"P Ciet","year":"2016","unstructured":"Ciet P, Serra G, Andrinopoulou ER et al (2016) Diffusion weighted imaging in cystic fibrosis disease: beyond morphological imaging. Eur Radiol 26:3830\u20133839","journal-title":"Eur Radiol"},{"key":"5539_CR44","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1002\/ppul.25664","volume":"56","author":"D Gr\u00e4fe","year":"2021","unstructured":"Gr\u00e4fe D, Anders R, Prenzel F et al (2021) Pediatric MR lung imaging with 3D ultrashort-TE in free breathing: are we past the conventional T2 sequence? Pediatr Pulmonol 56:3899\u20133907","journal-title":"Pediatr Pulmonol"},{"key":"5539_CR45","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1164\/rccm.201309-1659OC","volume":"189","author":"MO Wielp\u00fctz","year":"2014","unstructured":"Wielp\u00fctz MO, Puderbach M, Kopp-Schneider A et al (2014) Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med 189:956\u2013965","journal-title":"Am J Respir Crit Care Med"},{"key":"5539_CR46","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1148\/rg.2018170122","volume":"38","author":"EJ Monroe","year":"2018","unstructured":"Monroe EJ, Pierce DB, Ingraham CR et al (2018) An interventionalist\u2019s guide to hemoptysis in cystic fibrosis. Radiographics 38:624\u2013641","journal-title":"Radiographics"},{"key":"5539_CR47","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s00247-018-4304-8","volume":"49","author":"E Blumfield","year":"2019","unstructured":"Blumfield E, Swenson DW, Iyer RS, Stanescu AL (2019) Gadolinium-based contrast agents \u2014 review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients. Pediatr Radiol 49:448\u2013457","journal-title":"Pediatr Radiol"},{"key":"5539_CR48","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jcf.2015.11.009","volume":"16","author":"SB Donnola","year":"2017","unstructured":"Donnola SB, Dasenbrook EC, Weaver D et al (2017) Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients. J Cyst Fibros 16:283\u2013290","journal-title":"J Cyst Fibros"},{"key":"5539_CR49","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/nbm.3134","volume":"27","author":"A Fischer","year":"2014","unstructured":"Fischer A, Weick S, Ritter CO et al (2014) SElf-gated Non-Contrast-Enhanced FUnctional Lung imaging (SENCEFUL) using a quasi-random fast low-angle shot (FLASH) sequence and proton MRI. NMR Biomed 27:907\u2013917","journal-title":"NMR Biomed"},{"key":"5539_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12054","volume":"12","author":"L Behrendt","year":"2022","unstructured":"Behrendt L, Smith LJ, Voskrebenzev A et al (2022) A dual center and dual vendor comparison study of automated perfusion-weighted phase-resolved functional lung magnetic resonance imaging with dynamic contrast-enhanced magnetic resonance imaging in patients with cystic fibrosis. Pulm Circ 12:e12054","journal-title":"Pulm Circ"},{"key":"5539_CR51","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jcf.2016.07.008","volume":"16","author":"RP Thomen","year":"2017","unstructured":"Thomen RP, Walkup LL, Roach DJ et al (2017) Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients. J Cyst Fibros 16:275\u2013282","journal-title":"J Cyst Fibros"},{"key":"5539_CR52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1148\/radiol.09090039","volume":"255","author":"E Bannier","year":"2010","unstructured":"Bannier E, Cieslar K, Mosbah K et al (2010) Hyperpolarized 3 He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function. Radiology 255:225\u2013232","journal-title":"Radiology"},{"key":"5539_CR53","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.mric.2015.01.003","volume":"23","author":"JE Roos","year":"2015","unstructured":"Roos JE, McAdams HP, Kaushik SS, Driehuys B (2015) Hyperpolarized gas MR imaging: technique and applications. Magn Reson Imaging Clin N Am 23:217\u2013229","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"5539_CR54","doi-asserted-by":"publisher","first-page":"e209","DOI":"10.1016\/j.acra.2020.05.008","volume":"28","author":"MJ Couch","year":"2021","unstructured":"Couch MJ, Munidasa S, Rayment JH et al (2021) Comparison of functional free-breathing pulmonary 1H and hyperpolarized 129Xe magnetic resonance imaging in pediatric cystic fibrosis. Acad Radiol 28:e209\u2013e218","journal-title":"Acad Radiol"},{"key":"5539_CR55","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1016\/j.ejrad.2013.08.018","volume":"82","author":"G Bauman","year":"2013","unstructured":"Bauman G, Puderbach M, Heimann T et al (2013) Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients. Eur J Radiol 82:2371\u20132377","journal-title":"Eur J Radiol"},{"key":"5539_CR56","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jmri.27027","volume":"52","author":"L Behrendt","year":"2020","unstructured":"Behrendt L, Voskrebenzev A, Klime\u0161 F et al (2020) Validation of automated perfusion-weighted phase-resolved functional lung (PREFUL)-MRI in patients with pulmonary diseases. J Magn Reson Imaging 52:103\u2013114","journal-title":"J Magn Reson Imaging"},{"key":"5539_CR57","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00247-020-04638-9","volume":"50","author":"F Neemuchwala","year":"2020","unstructured":"Neemuchwala F, Ghadimi Mahani M, Pang Y et al (2020) Lung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot study. Pediatr Radiol 50:923\u2013934","journal-title":"Pediatr Radiol"},{"key":"5539_CR58","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/RLI.0b013e318074fd81","volume":"42","author":"M Puderbach","year":"2007","unstructured":"Puderbach M, Eichinger M, Haeselbarth J et al (2007) Assessment of morphological MRI for pulmonary changes in cystic fibrosis (CF) patients. Investig Radiol 42:715\u2013724","journal-title":"Investig Radiol"},{"key":"5539_CR59","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1148\/radiol.2019190797","volume":"294","author":"I Benlala","year":"2020","unstructured":"Benlala I, Hocke F, Macey J et al (2020) Quantification of MRI T2-weighted high signal volume in cystic fibrosis: a pilot study. Radiology 294:186\u2013196","journal-title":"Radiology"},{"key":"5539_CR60","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1007\/s00247-013-2867-y","volume":"44","author":"AD Calder","year":"2014","unstructured":"Calder AD, Bush A, Brody AS, Owens CM (2014) Scoring of chest CT in children with cystic fibrosis: state of the art. Pediatr Radiol 44:1496\u20131506","journal-title":"Pediatr Radiol"},{"key":"5539_CR61","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ejrad.2018.02.023","volume":"101","author":"P Leutz-Schmidt","year":"2018","unstructured":"Leutz-Schmidt P, Stahl M, Sommerburg O et al (2018) Non-contrast enhanced magnetic resonance imaging detects mosaic signal intensity in early cystic fibrosis lung disease. Eur J Radiol 101:178\u2013183","journal-title":"Eur J Radiol"},{"key":"5539_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194557","volume":"13","author":"P Konietzke","year":"2018","unstructured":"Konietzke P, Weinheimer O, Wielp\u00fctz MO et al (2018) Validation of automated lobe segmentation on paired inspiratory-expiratory chest CT in 8\u201314 year-old children with cystic fibrosis. PLoS ONE 13:e0194557","journal-title":"PLoS ONE"},{"key":"5539_CR63","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1007\/s00330-018-5516-x","volume":"28","author":"G Chassagnon","year":"2018","unstructured":"Chassagnon G, Martin C, Burgel PR et al (2018) An automated computed tomography score for the cystic fibrosis lung. Eur Radiol 28:5111\u20135120","journal-title":"Eur Radiol"},{"key":"5539_CR64","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1007\/s00330-020-06910-w","volume":"30","author":"I Benlala","year":"2020","unstructured":"Benlala I, Point S, Leung C et al (2020) Volumetric quantification of lung MR signal intensities using ultrashort TE as an automated score in cystic fibrosis. Eur Radiol 30:5479\u20135488","journal-title":"Eur Radiol"},{"key":"5539_CR65","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0173-2021","volume":"31","author":"P Ciet","year":"2022","unstructured":"Ciet P, Bertolo S, Ros M et al (2022) State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the \u201ciMAging managEment of cySTic fibROsis\u201d (MAESTRO) consortium. Eur Respir Rev 31:210173","journal-title":"Eur Respir Rev"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-022-05539-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-022-05539-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-022-05539-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:43:51Z","timestamp":1679885031000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-022-05539-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["5539"],"URL":"http:\/\/dx.doi.org\/10.1007\/s00247-022-05539-9","relation":{},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":["Radiology, Nuclear Medicine and imaging","Pediatrics, Perinatology and Child Health"],"published":{"date-parts":[[2022,11,14]]},"assertion":[{"value":"27 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}